Powder pains are among the most commonly prescribed medications. It was also the historically-known Venetian dryman containing opium, just like Paracelsus laudanum . Although classic anti-inflammatory and anti -inflammatory effects are common, today's analgesics are paralyzed .
Pure morphine (an opioid ) is now used for analgesia in lethally ill patients (mainly cancer patients ). Substantially wider use, however, has analgesics containing opioid codeine and other opioids . Codeine slowly changes into morphine in the body and is the core of dangerous addictive drugs - Alnagon and its clones. Other opioids are Tramadol and Tramal .
Less dangerous analgesics are cyclooxygenase inhibitors: Aspirin , ibuprofen (Brufen, Dolgit, etc.), paracetamol (Paralen, Panadol, Paramax, Coldrex) and others. These have become de facto pancakes today. They are prescribed universally and are used by men, women, children, sick, health and athletes to train more. Aspirin (acetylsalicylic acid) , available without prescription, was introduced into the Guinness Book of Records as the best-selling medicine in the world in the 1950s.
In fact, I have absolutely no certainty that aspirin-like analgesics are harmful. On the contrary, I know that, at least sometimes, cycloxygenase inhibitors are beneficial even for sustained use. The aspirin password today has more than 2,000 scientific reports that say what the most recent ( Sarbacker2016aup ) says - that regular doses of aspirin contribute to the prevention of cardiovascular and cerebrovascular events (stroke) mainly in the elderly. It is also not true that these substances are not "natural" - because aspirin naturally occurs in the corn. Vrbová bark is not an adaptogen , it contains tannins and defensive substances. Taking aspirin in a tablet is better than drinking odor from the willow bark, which I say as an advocate for natural treatments and adaptogens.
How do cycloxygenase inhibitors work?
Like any police system, the immune system also uses communication . However, immune cells do not use the transmitters, but a special class of chemical molecules called prostanoids . There are many species of prostanoids to transmit different signals, but all of them are produced by the rolking of arachidonic acid by the enzyme cycloxygenase. And it is precisely the purpose of the inhibitory action of all of these powders on aspirin-like pain. If the cycloxygenase is discontinued, the whole immune system will fall into forced radio silence. Inflammation stops , pain stops , often to the patient's great pleasure. However, it is questionable whether the complete elimination of prostanoid communication is the optimal approach.
This article does not look as bad for analgesics as negatively as I would. I do not like analgesics, and I usually prefer to tolerate pain in the hope that my body knows what she is doing and that I will heal more quickly. But in some cases, for example, in the case of fatally ill, I also acknowledge the benefits of analgesics, including those of opioids.
An alternative to opioid analgesics is cannabinoids, substances found in cannabis. Cannabinoids have a well-known analgesic effect ( Elikkottil2009apc , Walker2002can ) and cannabis (marijuana) on prescription is available nowadays ( , pharmacy map ).
How cannabis works
Like opioids have their natural counterparts in our brain - endorphins - even cannabinoids have their natural counterparts - endocanabinoids. For cannabinoids and endocannabinoids, we have 2 receptor types in the body: CB 1 and CB 2 . CB 1 is present in the brain and cerebellum. CB 2 occurs mainly in the immune system: T and B lymphocytes, macrophages and other white blood cells. While influencing CB1 receptors causes marijuana to have its well-known psychotropic effects, its anti-inflammatory ( Turcotte2016cri ) and analgesic effect ( Shang2016ccr ) is explained on CB2 . Cannabinoids even have the potential to treat autoimmune diseases ( Katz2016mca ).
However, cannabis is not an adaptogen. Some people like his psychotropic effects. I would like to remind you that if you smoke so well you can not stand upright and keep on your feet due to the influence of cannabinoids on CB 1 receptors in the cerebellum. Like cannabis does not improve the ability to walk, I suspect that by acting on CB2 receptors it does not increase the overall condition of the immune system. Smoking marijuana damages more than smoking tobacco. While nicotine narrows the trachea, cannabinoids expand them. Smoke goes deeper into the lungs, not to mention that jointy packs without a filter. Inactivation of immunity is undesirable in the lungs as it aggravates their self-cleaning ability and resistance to infection ( Turcotte2016icc ). It is better to use cannabis as a meal (cannabinoids from the resin are hard to lean). Hemp recipes can be found here, for example .