Hepatic cancer, more precisely hepatocellular carcinoma (hepatoma), is the most common primary malignant tumor of the liver. But before I continue with the hepatoma, let's first say about the secondary ones. Malignant tumors in the liver are divided into primary (in the liver) and secondary (metastases of tumors originating elsewhere). Since the liver performs the function of a blood filter flowing out of the entire digestive tract, there is approximately 20 times more evidence of secondary tumors in the liver - metastases of the esophagus, stomach, small intestine , colon and rectum . Primary malignant liver tumors, as has been said, are dominated by the hepatoma. Minority of primary liver malignancies forms other types of tumors, including cancers of the gall bladder and bile ducts arising from the bile duct epithelium.
The hepatocellulosis itself from hepatic cells - hepatocytes. Due to the chemical load that the liver suffers, hepatocytes have to maintain their regeneration capability and thus make cancer easier to develop ( similarly to mammary carcinoma ). Induction of hepatocyte proliferation occurs when existing liver lobes are worn or destroyed (necrotic) due to chemical and biological stress. Hepatoprotective adaptogens increase the ability of the liver to withstand the burden and thus reduce the risk of liver cancer. There is also a link between liver cancer, liver inflammation (hepatitis) and cirrhosis - liver shedding . Inflammation of the liver is a symptom of liver poisoning and infections and increases the risk of liver cancer. Even worse is the situation with cirrhosis, when hepatocytes are in a frustrating situation: they are called for division and regeneration, which the accumulated fibrotic tissue does not allow for spatial reasons. Therefore, in cirrhosis, hepatocytes often "rupture in the crate" and begin to divide uncontrollably. Textbooks of hepatic poisons are benzene, CCl 4 and mycotoxins, for example aflatoxin A. Dangerous but also infectious jaundice, especially infectious hepatitis B , whose virus has a tendency to integrate at random sites of hepatocyte DNA and randomly trigger various oncogenes.
Treatment and prevention of liver cancer
We can treat liver cancer (as well as cancer in general) in two ways. The first one is to be young, not to think, to do and to eat what we have the taste and especially to have a lot of offspring in the early age who will prevent liver cancer in the same way. This is what the rats, rabbits and many other animals do - even from these can be learned. If we prevent liver cancer in this way, it is important to avoid any knowledge of cancer and to ignore the existence of cancer patients. As a weak individual behind the herd and their destruction, natural predators will be taken care of. The second way is to remember the most important hepatoprotective and anti- cancer adaptogens (apart from what the doctors can do to us) and we will put them into the menu according to their possibilities. This is what people have been doing since the time of the past, although instead of adaptogens and science, we once had only faith and magic. And those readers who expected the introduction more pragmatic and boring, I refer to an article about cancer in general .
Adaptogens against hepatoma
Adaptogens are generally used in cancer for both direct anticancer effects and supportive therapy for regenerating the organism after chemotherapy and radiotherapy. But we must realize that the hepatoma has a very poor prognosis, and the use of adaptogens usually does not lead to complete cure. Total hematoma remission is a small medical wonder to which adaptogens can contribute, but doctors do not always know because patients are not always informed about their decision to use adaptogens ( Gordan2011awo ).
The effect of ginseng on liver cancer
The anti-cancer effects of ginseng have been given great scientific attention. Ginseng suppresses inflammation and reduces the risk of cancer ( Hofseth2007ict ), as confirmed by the randomized clinical trial of Yun2010npe . At the level of individual panaxosides, the anticancer effect of ginseng is dedicated to Choi2013bbc , see also the relevant paragraph in the article on cancer in general . Discussion of general anticancer effects is here because 95% of malignant liver tumors are metastases of tumors originating elsewhere. Regarding the effect on primary liver tumors, ginseng in animal carcinogenicity reduced the incidence of liver cancer and had cytostatic effects on hepatoma cells ( Kim2013pge ). The panaxoside compound induced apoptosis of hepatoma cells ( Song2010imc ) by acting on a specific pathway.
The effect of glans against liver cancer
The most well-known mushroom adaptogen in TČM is glossy glossy glass , the use of which has been recorded in professional medical literature for 2000 years. TČM used it to treat a wide range of diseases. It has also been the subject of extensive research and demonstrated anti-cancer, antidiabetic, hepatoprotective, antiviral and immunomodulatory effects ( Chen2017clt ). All of these are used in its effect on liver cancer. Lesklokorka belongs to adaptogens whose effects are mediated on the one hand by the triterpenoid fraction (ganoderic acids and the like) and by the specific proteoglycans. Like all mushrooms, the gloss has a non-specific anti-cancer effect due to its content of ergosterol ( Chen2009ca9 ), β-glucan ( Pillai2013mbg ) and other common fungal metabolites.
As regards specifically liver cancer, in addition to the anticancer properties of glans, it also has its hepatoprotective effect . According to Lakshmi2006aam, the glossy shield protects the liver from damage and cancer during experimental poisoning with benzpyrene. Chen2017clt notes the effect of glomerular triterpenes against the hepatoma cell line, which was previously known ( Yang2005gap and others). Taiwan's Lin2003teg study found that the triterpene component of glossary stops stops dividing hepatoma cells in G2 by specific gene expression. According to Lu2012aaa, the acid component of the extract stops the hepatoma cell cycle in the G1 phase, the neutral component in the G2 / M phase. Chang2006ggt reports the efficacy of ganoderiol F against hepatoma cell lines in vitro , Weng2009ieg inhibitory effect of lucidic acid on both the growth and malignancy of in vivo liver cancer. Lucenidic acid also finds effective Weng2010aer . An effective concentration in which specific triterpenoids of glans inhibit hepatoma growth is 20-80μM according to Ruan2015drc. Healthy liver cells do not damage the gloss ( Liu2012pgl ). In addition, ganoderic acid B has been shown to have an effect against normal cytostatic resistant ( Liu2015gld ) liver cancer cells. The effect against the hepatoma was also found in sputum lice ( Liu2002aas ).
According to Li2015glp, glossary liver in liver cancer increases the activity of cytotoxic T lymphocytes that fight cancer. Immunomodulatory effect in experimental liver cancer is confirmed by Zhou2009egl . Triterpenes of glans also act against secondary tumors (ie metastases of other tumors) in the liver ( Kimura2002aae ).
Appropriate clinical studies on gloss performance in human hepatoma patients do not exist compared to other plant and fungal adaptogens. But we should not underestimate the anticancer potential of mushrooms and glans. As Gordan2011awo illustrates , cases of successful remission of hepatoma have been reported in patients receiving these adaptogens, which is otherwise not a common phenomenon.
Other adaptogenes against liver cancer
What he prescribes for hepatic cancer, Taiwanese TCE, and scientific phytomedicine basically sums up the Ting2015ptr report (full article available online), an important site here, for example, is the Bajkal Shihash . According to Kan2017sbd, it is related to a beard bearded by an effective immunomodulator and an inhibitor of hepatoma growth in vivo .
Jellyfish is a known adaptogen with a protective effect on the liver . The current state of knowledge about its protective effect against liver cancer is Mastron2015shc . According to Elmesallamy2011ceg, it protects the extract of the oystercatcher and ginkgo biloba from the development of liver cancer.
Plant research with hepatoma potential is also popular in China (16086244, 19230404, 19368349, 24692683). 24716182 investigated cinnamaldehyde and the Huang-Lian-Jie-Du-Tang mixture. Cinnamonum Cinammomum verum cinnamon examined 26792981. Greek hay fescue was the subject of study 26557712. Momordiku (bitter cucumber) was investigated by study 25200916. The effect against in vitro hepatoma was also found in in vitro cytomegalovirus ( Huang2007maa , Huang2009czj ). Chinese ganglion has been shown to act against human hepatoma cells in vivo ( Shang2003esa ). The hepatoprotective and anti-inflammatory herbs TČM draws attention to 27043533. Bajkalin, which is found in the baykalis, causes apoptosis of hepatoma cell lines ( Yu2016bps ), see also 24910406. Bajkalin is also present in the Oroxylum indicum . According to Liu2006mmc Epimedium C ( Epimedium grandiflorum , E. sagittatum ), the cell cycle of the hepatoma cell line was stopped by a specific effect on the cell signaling cascade.