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Hepatic cancer (hepatoma)

Hepatic cancer, more precisely hepatocellular carcinoma (hepatoma), is the most common primary malignant tumor of the liver. Before I continue with the hepatoma, let's say first that the malignant tumors in the liver are divided into primary (produced in the liver) and secondary (resulting elsewhere with metastases to the liver). The liver performs the function of a blood filter, so other tumors that occur in the liver are metastasized very often. Therefore, there is a 20-fold increase in the incidence of secondary tumors in the liver than in the primary hepatoma. The most common are metastases from the digestive tract (the large and small intestine, stomach and esophagus) that are directly connected to the liver via the portal circulation. This does not mean that primary liver and hepatic tumors are unimportant. Hepatoma is a highly malignant cancer that physicians do not really know about - like brain tumors. Any effective herbal aid is welcome in the hepatoma. A minority of primary liver malignancies form other types of tumors, such as gallbladder and bile duct cancer, liver sarcoma,

Hepatoma is cancer in the narrower sense of the word. Hepatoma comes from liver cells - hepatocytes - which are actually the glandular epithelium of the liver beams. Because of the chemical burden that hepatocytes tolerate, these cells must retain their ability to divide and regenerate. As a dividing cell, the cancer is more likely to develop. (A similar situation exists in mammary carcinoma .) Hepatocyte proliferation occurs when hepatic damage or wear. Hepatoprotective adaptogens protect the liver from damage, reduce the burden that hepatocytes have to take and thus reduce the risk of hepatoma.

Hepatic impairment is usually associated with hepatic inflammation (hepatitis) and with persistent exercise with cirrhosis - liver hardening . Liver inflammation is a sign of poisoning and infection . The destruction (necrosis) of hepatic lobules induces hepatocyte regeneration and proliferation, thereby increasing the risk of hepatoma. Even worse is the situation with cirrhosis, where hepatocytes are frustrated by the need for liver regeneration, which, however, due to the accumulation of fibrotic tissue can not be done. In cirrhosis, therefore, hepatocytes often "go crazy" and start to divide uncontrollably. Textbook liver poisons (benzene, CCl 4 , mycotoxins - for example, aflatoxin A) are therefore also an effective liver carcinogen. However, the risk of hepatoma also increases infections where the inflammation of the liver occurs due to bacteria or viruses (infectious jaundice). Primary liver cancer risk increases in particular the type B infectious hepatitis virus, which has the ability to integrate into hepatocyte DNA sites and its promoters to contribute to malignant overthrow.

Treatment and prevention of liver cancer

We can treat liver cancer (as with cancer in general) in two ways. The first one is to be young, not to think, to do and to eat what we have the taste of, and especially to have a lot of offspring at an early age, who will prevent liver cancer in the same way. This is what rats, rabbits and many other animals do - even from these can be learned. If we prevent cancer in this way, it is important to avoid any knowledge about it and to ignore the existence of the hepatoma of the "losers". As a weak individual behind the herd and their destruction, the predators will be taken care of. The second way is that we still remember the most important hepatoprotective and anti-cancer adaptogens, and these will be sorted into their diet. That's what people have been doing since ancient times, even though we used to have faith and magic instead of science. Readers who startled this introduction and want less humor, I refer to an article on cancer in general .

Adaptogens against hepatoma

Adaptogens in liver cancer work in three ways: preventive, curative and supportive. The preventive effect is to protect the liver and improve its ability to withstand chemical and infectious stress. The therapeutic effect is associated with the direct anticancer effects of some herbs. The supportive effect promotes regeneration in standard chemotherapy and radiotherapy of hepatoma. The effect of adaptogens against liver cancer is real, but it is not clear from the point of view of scientific medicine which plants and fungi are the most suitable and how to use them specifically. The following text will therefore deal with the hepatoprotective and healing effect:

  1. Plant adaptogens and their representatives of ginseng, whose effect on cancer is mainly supportive.
  2. Mushroom adapters and their representatives glossy gloss with direct anticancer effects.
  3. Recipe of TCM, which has been developed by standard physiotherapy procedures in the treatment of liver cancer.

For the healer who is standing in front of a practical case of cancer, these possibilities are probably the best way of presenting TČM, who confidently offers a comprehensive, traditionally proven paraveday system of phytotherapy. Note, however, that the hepatoma is difficult to heal and total remission is a small medical miracle. Adaptogens contribute to hepatoma treatment ( Gordan2011awo ), but miracles do not guarantee. There is no guaranteed herbal strategy against hepatoma.

The effect of ginseng and plant adaptogens against liver cancer

The anti-cancer effects of ginseng have been given great scientific attention (see the relevant paragraph for cancer in general ). Ginseng suppresses inflammation and reduces the risk of cancer ( Hofseth2007ict ). This is confirmed by the clinical study Yun2010npe . The effects of individual panaxosides are analyzed by Choi2013bbc . The effect of ginseng on liver cancer (hepatoma) is mainly studied by Kim2013pge , Song2010imc and others. According to these, ginseng reduces the incidence of liver cancer by carcinogens and acts directly against hepatoma cells.

Marshmouth thistle is a well-known adaptogen with a protective effect on the liver known to all Czech herbalists. Its effect on liver cancer is not negligible, the recent scientific review is Mastron2015shc . According to the study, Elmesallamy2011ceg protects the extract of oyster grass and ginkgo biloba from the development of liver cancer. The anti-cancer effects of another classical adaptogen, the pink rosary , highlights the Russian Bocharova1994tpe review , which considers the stapler to be more efficient than glossy gloss.

The effect of glans and spice adapters against liver cancer

The most well-known mushroom adaptogen is glossy glossy glass , which owes its fame to TČM. In the Far East, glossary is considered to be an important drug in the prevention and treatment of cancer. Its effects are specific triterpenoids (ganoderic and lucidic acids, ganodieriols and others) and specific proteoglycans. Scientifically, its effects against hepatoma in vivo and in vitro have been confirmed by studies of Yang2005gap , Liu2009eaa , Lu2012aaa , Li2015glp and others. The effect against the hepatoma was also found in sputum gloss ( Liu2002aas ). Healthy liver cells do not damage gloss ( Liu2012pgl ).

The anti-cancer, anti-diabetic, hepatoprotective, antiviral and immunomodulatory effects of glossy-acid are well known in the art and are also applied to the hepatoma. You can find references in the recent Chen2017clt report. According to Lakshmi2006aam, the glossy shield protects the liver from damage and cancer during experimental poisoning with benzpyrene. According to Taiwan's Lin2003teg study, the triterpenoid glomerular component stops the hepatoma cell division in G2 by specific gene expression. According to Li2015glp, the gloss liver in liver cancer increases the activity of cytotoxic T lymphocytes that fight cancer. Chang2006ggt reports the efficacy of ganoderiol F against hepatoma cell lines in vitro , Weng2009ieg the inhibitory effect of lucidic acid on both the growth and malignancy of in vivo liver cancer. Lucenidic acid also finds effective Weng2010aer . For ganoderic acid B, there was an effect on cells resistant to normal cytostatic ( Liu2015gld ) liver cancer cells. Concentrations of specific triterpenoids of glans effective against hepatoma are 20-80μM according to Ruan2015drc. Triterpenes of glans also act against secondary tumors (ie metastases of other tumors) in the liver ( Kimura2002aae ). A certain amount of weight has oral and written ( Gordan2011awo ) reports of unique "miraculous" healings of patients suffering from hepatoma after gloss.

The Fungi addition generally contains adaptogenic substances with anticancer effect. All sponges (including glossy gloss) are the source of adaptive ergosterol ( Chen2009ca9 ), β-glucan ( Pillai2013mbg ) and other common mycochemicals. For example, another classical anti- cancerous fungus, a rusty oblique , documents its effect against the hepatoma cells of Song2008iio and Youn2008cmi .

Recipes used in liver cancer

Traditional Chinese medicine has its established recipes in individual cancers, including liver cancer. In the hepatoma, these recipes summarize the Taiwanese overview of Ting2015ptr (full article available online). One of the most important anticancer herbs in the Czech Republic is the Baikal Shihak and related bearded Shihashi , which according to Kan2017sbd is an effective immunomodulator and inhibitor of hepatoma growth in vivo .

Plant research with a potential for hepatoma is also popular in China (24692683). 24716182 examined cinnamaldehyde and the Huang-Lian-Jie-Du-Tang mixture. The cinnamon Cinammomum verum examined 26792981. The hayworm was studied in the study 26557712. Momordiku (bitter cucumber) was investigated by study 25200916. The effect against hepatoma in vitro was also found in the in vitro data cyst ( Huang2007maa , Huang2009czj ). The Chinese angiogenesis has been shown to act against human hepatoma cells in vivo ( Shang2003esa ). On hepatoprotective and anti-inflammatory herbs TČM draws attention to 27043533. Bajkalin, which is found in baykalis, causes apoptosis of hepatoma cell lines ( Yu2016bps ), see 24910406. Bajkalin is also present in the Oroxylum indicum . According to Liu2006mmc Epimedium C ( Epimedium grandiflorum , E. sagittatum ), the cell cycle of the hepatoma cell line was stopped by a specific effect on the cell signaling cascade.

The experience of oriental medicine is now also used in complex scientific hepatoma therapy. The recent overview of the hepatoma Rasool2014nph offers, in addition to the latest immunotherapy, three traditional herbal blends:

  1. sho-saiko-to (Xiao Chai Hu Tang, Minic Bupleurum Formula, Radix bupleuri 24g, Radix scutellariae 9g, Rhizoma pinelliae 9g, Rhizoma zingiberis recens 9g, Radix et rhizoma ginseng 9g, Radix et rhizoma glycyrrhizae praeparata 9g, fructus jujubae 9g )
  2. shen-qi (angelicae dahuricae radix 20g, sconellariae radix 10g, lantonerae japonicae flos 10g, menthae haplocalycis herba 10g, isatidis indigoticae folium 10g, taraxaci mongolica herba 10g, astragali radix 30g, codonopsis radix 30g, agrimoniae pilosae herba 30g, asari sieboldii radix et rhizoma 5g)
  3. shi-quan-da-bu-tang (all-important great tonic decoction): radix astragali 6-10g, cinnamomic cortex 3-6g, radix ginseng 6-9g, radix rehmaniae prepared 9-15g , rhizoma atractylodes macrocephalae 9-12g, radix angelicae sinensis 9-12g, radix paeoniae albae 6-9g, radix chuanxiong 3-6g, sclerotium poriae cocos 6-9g, radix glycyrrhizae 3-6g says americandragon) (rehmannia glutinosa, paeonia lactiflora, ligusticum wallichii, angelica sinensis, glycyrrhiza uralensis, poria cocos, atractylodes macrocephala, panax ginseng, astragalus membranaceus and cinnamomum cassia says 1294861).

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