The current pharmacological concept of the drug in Western (Euro-American) drug practice has long been Paracelsus. Although adaptogens and medicinal plants are once again gaining recognition, it is appropriate to clarify that drug assessment and all pharmaceutical legislation are still implicitly governed by Paracelsus' view.
Paracelsus and its pharmaceutical innovations
In the 16th century, Paracelsus was a great pioneer in the use of minerals and inorganic substances in European pharmacotherapy, which was based mainly on herbs. He has succeeded in treating syphilis with mercury-treated salts in small doses; he has been banned from publishing after he has rightly described the guajak wood used to date to be inactive against syphilis. The true stories that Paracelsus has dealt with witchcraft, alchemy, hermetism, exploration of the so-called mineral signatures, the production of amulets, and the refusal to treat the astral body as defamation. On the other hand, I see their attempt to generalize medical science, which has gotten a better form in the 20th century in the unified theory of medicine , which the term adapogen follows. In this sense, Paracelsus and modern scientists dealing with adaptogens tried to do the same. Chronic poisoning with arsenic and mercury compounds eventually left Paracelsus himself alone . After his death, the glory of Paracelsus drugs continued to grow, mainly in the treatment of syphilis and generally in antibacterial substances, culminating in the discovery of salvarsan, antibiotic compounds of bismuth, penicillin, sulfonamides, tetracycline and modern antibiotics ( Aminov2010bha ).
In the hilt of his sword, Paracelsus wore his secret remedy - laudanum - which he only conserved for the most difficult and fatally ill. It was an opioid analgesic in the form of small pills . Opioids are used to treat palliative care for those who are still ill.
According to the Paracels maxima " sola dosis facit venenum ", each active substance is poison or drug depending on the dose. This maxim is illustrated by the fact that even water or glucose can be poisoned in sufficient quantity. Paracelsal drug therapy is also used to treat poisonous substances whose potency is expressed by the therapeutic index - an overdose of an effective dose (ED 50 ) to a toxic dose (LD 50 ) (see wikipedia ). In this case, an effective dose of ED 50 is one in which 50% of patients are cured or, depending on the type of disease, a 50% adjustment of the patient's condition occurs. The toxic dose LD50 is that in which 50% of laboratory animals are degraded (converted to kilogram live weight). According to Paracelsov's view, each drug is linked to a specific indication - the so-called main effect, whose ED 50 enters the therapeutic index. Other effects are referred to as side effects. Paracelsus' view of the drugs is as follows:
Paracelsus paradigm of the drug
- Each drug has a specific indication (main effect) and has an effective dose (ED 50 ).
- Each drug is a poison and each drug has a lethal dose (LD 50 ). The LD 50 / ED 50 ratio expresses the quality of the drug.
- Effects beyond the main effect are referred to as side effects.
When I say that today's legislation follows the above-mentioned view, I do not overdo it. It does not distinguish between poisons and medicines. It only distinguishes between strong and weakly active substances. For example, Decree of Ministry of Health of the Czech Republic No. 343/2003 Coll. Separates the medicinal plants to "very strong", "highly effective" and "others used", and the deadly poisonous plants (spruce, hellebore, bayonet, oleander, mandragory, Highly effective ". Adaptogens are generally classified as "other used", ie implicitly ineffective. The non-distinction between drugs and poisons also means that pharmaceutical laws inherited from the 20th century do not talk about drug toxicity but about so-called "side effects".
Paracelsus' view of adaptogens can not be balanced
Paracelsus's legislative view of adaptogens does not matter. They view them as food ("food supplements"), placebo ("herbs"), or as panacea. Good adaptogens do not have LD 50 and therefore their therapeutic index can not be quantified. Adaptogens also have no major effect. An effective dose of adaptogen (ED 50 ) in specific indications can be measured, but this does not reflect the overall quality of the adaptogen. This problem has been solved only by the definition that introduces the adaptogen as a separate drug ideal , to which the real pharmacist may be more or less close.
I do not see Paracelsa or today's legislators ignorant of the fact that there are even harmless effective drugs. Paracelsus was a pioneer worthy of respect. It is not that any theory he created has led the legislature today to a shame. The Paracelsus paradigm chose the legislation because it best suits its interests. Drug legislation has largely been introduced in response to poison scandals, such as cocaine and opium pills from the 1920s, free-range radioactive preparations for internal use from the 1930s, and thalidomide scandal of the 1950s. Institutionalization of medicines, including harmless medicinal plants, is only one of many facets of progressive institutionalization of all aspects of human life and the progressive buildup of laws and decrees that has proven to have occurred in the 20th century without leading to a fairer world. (See also comparisons of adaptogens and Paracelsus drugs .)