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Neuroprotective effects

Protection of brain cells (neurons)

Neuroprotective effect = protection of brain cells (neurons) from damage and death

Damage to neurons may be due to stress, alcohol, narcotics, or other poisons. Neuroprotective effect generally means a soothing effect on microglia (which are modified CNS-based macrophages that serve neurons, respond to brain defense and cleanse dead cells).

It turns out that excessive activation of microglia damages the brain. Mental stress , neural poisons , autoimmune processes , stroke and other illnesses have common brain damage by activating microglia. The microglia sensitively responds to brain damage and even to mere mental overload. Microglia plays an immune and cleansing role in the brain. But in situations like brain stroke, hangover , or even mental stress from today's lifestyle, the microglie can not adjust its activation to do more harm than good. It is the microglia that is responsible for severe headaches in hangover and other situations.

Significant properties of adaptogens include neuroprotective effects

Neuroprotective effects of ginseng

This effect has been extensively investigated in the ginseng model adaptogen ( Zhang2008pgg , Li2007peg , Wu2007deg , Lin2007gra , Liao2002neg ) and has been found with other adaptogenes. In all these cases, neuroprotective ginseng-type adaptogens have a chance to help.

Ginseng contains substances that have the ability to calm the microglia and therefore have a positive effect on hangover, traumatic injury (trauma, shaking of the brain), and other conditions mentioned above. The way this panaxoside achieves is also related to the immunomodulatory and anti-inflammatory effects of ginseng.

  • Wu2007deg shows that gssd. Rb2 , Rd , Rg1 and Re have a strong inhibitory effect on the production of TNF-α microglia-activated lipopolysaccharides. Gssd Rg 1 and Re also block microglia production of NO. Their inhibitory effect on NF-κB transcription factor and other elements of the stress microglia activation cascade (MAPK1, MAPK3, MAPK8) has been confirmed.
  • In experiments on neuronal cultures, it has demonstrated a protective effect by limiting the microglia inflammation response and reducing the production of NO and prostaglandin E2 induced by the addition of bacterial lipopolysaccharides ( Lin2007gra ).
  • Pxsd. Rb 1 and Rg 1 had a protective effect on spinal neurons in vitro ( Liao2002neg ).
  • Bae2006grr illustrates the protective effect of ginseng on ischemic stroke with the gssd suppressive effect. Rg 3 and Rh 2 to detrimentally activate the microglia. Lipopolysaccharide-activated or interferon-γ activated mice blocked Rh2 expression of inducible NO synthase (NOS2 gene), and production of NO with IC50 = 17 μM by blocking the binding of transcription factor AP-1 to DNA. This also reduced the expression of cycloxygenase 2 (the PTGS2 gene) and the inflammatory cytokines TNF-α and IL-1β. Rh 2 further increased the expression of IL-10 inhibiting inflammation and facilitated the binding of the CREB transcription factor to the DNA. There was no Rh 2 effect on the binding of NF-κB transcription factor. Effect of gssd. Rg 3 was similar to Rh 2 , but much weaker.
  • Gssd Rg 2 prevents neuronal death, protects memory and other brain functions in the ischemia / reperfusion model ( Zhang2008pgg ), and protects the glutamate damage ( Li2007peg ) in vitro.
  • Ginsenoside Rd prevented damage to dopaminergic neurons due to inflammatory activation of microglia by bacterial lipopolysaccharides. ( Lin2007gra )
  • Ginsenoside Rg 3 , which is primarily produced by ginseng on red ginseng , reduces the expression of cytokines in inflammatory activated microglia and inhibits the binding of NF-κB transcription factor to appropriate DNA binding sites, resulting in increased survival of neuronal cells in vitro. Ginsenoside Rg 3 also almost completely blocked the expression of NOS2 (iNOS) and increased the expression of MSRA (macrophage scavenger receptor type A). ( Joo2008pin )
  • Ginseng polysaccharides protect the brain from autoimmune damage in an experimental mouse model ( Hwang2011app )
  • Nie2006pep - ginseng panaxynol and panaxydol protect brain neurons subjected to chemical stress before dying.

Neuroprotective effects of LBP polysaccharides contained in the pasta.

Publications on the neuroprotective effect of the polysaccharides of the pasta came from a group of scientists at Hong Kong University, mainly from in vitro experiments, at a time when I was intensively engaged in the subject. Previous treatment with the LBP aqueous extract has protected rat cortex neurons from the Aβ toxicity (amyloid beta is a protein that appears to be the major constituent of plaque in the brain of Alzheimer's disease ) ( Yu2005nea ). In one of the rare in vivo studies, the effect of LBP on glaucoma was investigated by high intraocular pressure. LBP-feeding rats showed a significant reduction in the number of retinal ganglion neurons. However, the intraocular pressure did not change ( Chan2007nel ). It is virtually certain that over time, the researchers will discuss the neuroprotective effect of the clergyman, in which readers refer to primary sources.

Other neuroprotective adaptogens

Neuroprotective effects were found in many adapogenic and medicinal plants. From specific publications, I draw attention to:

The plant with these effects must, of course, be much more than I can mention and document in this short paragraph. In addition, there are new reports every year on this topic, so I have to refer you to the primary sources again for the latest information. Note, however, that many neuroprotective substances come from spices (curcumin and others) or common foods (resveratrol, quercetin). I would therefore like to draw attention to the book "Spices and Its Medicinal Effects" by the famous prof. Pavel Valíček, where the healing effects of spice are documented more systematically.

| 24.12.2009