In some professions, mental performance is a critical factor and its maximization is needed by all those who practice these professions. I have already written about mental stress and the effect of adaptogens on him in another article . Here I deal with the methods by which healthy people can increase their mental performance. Sometimes, it's just a relaxing exercise, in which we try to relax and better focus on the mental activity we perform.
Nootropics - substances improving mental performance
Nootropics are defined as intelligence-enhancing or other (e.g., calming) thought-improving. Of course, it is more a desire than a reality, the intelligence is too complex to be able to increase in human beings by using some substance. Nootropics are, in practice, mostly substances improving a brain physiology parameter, for example, blood circulation in the brain or the availability of neurotransmitters. They do not work for all people, but only for those who have a problem with the physiological parameter - because the brain completely healthy will ensure seamless enough blood circulation and the availability of transporters. Other nootropics are derived from psychiatric drugs, in the expectation that what helps weakened individuals can boost the normal brain to higher performance. (Well-known piracetam is something between these two categories.) Other substances do not function as nootropic only by their calming effect - maybe you did not know that common ethanol is forbidden as doping in competition shooters just because of a calming effect. Finally, I would like to mention the category of nootropics, which are, from my point of view, the most important biologist, and these are natural adaptogenic nootropics.
Genuine Genuine is a well-studied nootropic
Improvement in average mental performance (nootropic effect) has been a subject of great interest in ginseng and is documented by many publications. Scientific research on its efficacy is important because the subjectively felt effect of ginseng on improving thinking and working concentration is difficult to distinguish from the placebo effect. We can build on gossip like nootropics with faith or unbelief, but with the fact that nootropic effect is the number of studies with which other herbs can hardly compete. The nootropic effect of ginseng is explained by three main mechanisms:
- Calming (anxiolytic) action through the GABAergy system .
- Positive effects on memory over the central acetylcholine system .
- Other neurosteroidal effects of panaxoside on the serotonin and dopamine system.
Calming effect through the GABAergy system
Ginsenosides Rb1, Rb2, Rc , Re , Rf and Rg1 reversibly bind to GABA receptors ( Kimura1994igw ). Like piracetam, ginseng also stabilizes the activity of GABA neurons . This helps with negatively motivated tasks, as confirmed by animal studies ( Churchill2002npg ). Ginseng, although not euphoric, helps with depression . and removes insomnia .
Improving memory due to the acetylcholine system
Gssd. Rb 1 ( Benishin1991egr ) and Rg1 ( Yamaguchi1995egi ) together with gssd. Re ( Yamaguchi1996egi ) block experimental damage to alkaloid learning by scopolamine. Ginsenosides Rb 1 and Rg 1 enhance the metabolism of acetylcholine in the hippocampus ( Benishin1992agr , Salim1997grr ). Gssd. Rg 2 , Compound K and protopanaxatriol inhibit specific types of nicotinic cholinergic receptors ( Lee2003deb , Lee2009rlr ).
Other psychic effects of ginseng
Ginseng regulates stress, activates the psyche and removes the psychic feeling of fatigue ( Kim2003iii , Yoshimura1988ace , Kim2003egs ). Gssd. 20 (S) Rg2 improved learning and memory in rats and restricted experimental disturbance of the psyche ( Ma1993e2c ). The use of ginseng in the context of psychiatric treatment is discussed by Wilkie1994grj . Consideration has also been given to the use of ginseng in Alzheimer's disease , which grossly disturbs thinking. I was wearing a very high dose of ginseng (up to 30g a day for 2 weeks) for signs of hyperactivity and irritation. However, the mouse Yoshimurassa study observed aggression reduction of panaxoside Rb 1 after pancreatic extract, while panaxoside Rg1 increased aggressivity. (The adverse effects of content are typical for ginseng.)
Clinical studies confirming the nootropic effects of ginseng
- Standardized ginseng extract G115 improved work memory and subjective mental well-being of healthy young probands (30 volunteers, 8 days after 200 and 400 mg extract, Reay2010pgg , tests from this and several other publications made by G115, Boehringer Ingelheim).
- Ginseng Korea Insam and G115 extract improved attention, intelligence (numeracy tasks, logic) and response time (16 probands, Angelo1986dpc ).
- In young probes, ginseng improved performance in a ten-minute stress test ( Reay2006epg )
- The combination of ginseng and ginkgo biloba improved mental performance in detailed psychosocials ( Kennedy2002mcm ).
- Kallus2005apf is a scientific review of the aging of cognitive functions , and finds a positive effect on caffeine and ginseng extract G115. ( I'm more cautious about caffeine .)
- Coleman2003epg is an overview of the positive effects of P. ginseng on quality of life, focusing on Pharmaton, Ginsana, and the like.
- The nootropic effects of herbal combination with ginseng and schizander (cloning) were investigated by Nishiyama1995bes and Nishiyama1996hps , which showed improvement in learning and memory.
- The standard TCM combination of yen ken ginseng and polygala tenuifolia had an anti-depressant and nootropic effect on the animal model. ( Sun2013aem )
Another plant nootropic
In addition to ginseng, the nootropic effect is often attributed to ginkgo biloba , pink rosary , Chinese schizander, and, to varying degrees, other adaptogens. Baikal Shihak is slightly sedative and has protective effects on hippocampal neurons ( Lim2016asb ). Sage and other deaf, such as oregano, deserve attention. The traditional Indian (Ayurvedic) nootropic is a bastard, called Brahmi ( Calabrese2008esb ).
As a bead, I would say that the most commonly used nootropic is nicotine, the nootropic effects of which my former head, the neurobiologist and the big smoker himself like to point to. Nicotine acts on central nicotinic acetylcholine receptors. Although nicotine is not an adaptogen (its therapeutic index is too low), it improves concentration in small doses, and temporarily suppresses the symptoms of Parkinson's disease in the elderly.