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Chemical stress (for example, chemotherapy)

The concept of adaptogen is related to the concept of stress, which in its broad meaning refers to any burden on the body. While the physical and mental load or the radiation load is intuitively well enough to know what it is, chemical burden is a less common term that literally includes all the poisons and extraneous chemicals that act in the environment on the organism. Adaptogens that protect against chemical load are called chemoprotective .

Chemoprotective properties of adaptogens

The chemoprotective effects of adaptogens do not form a distinct category, but according to a particular kind of poison, they are combined with antioxidant ( oxidant ), neuroprotective (neurotoxin), anti-tumor (carcinogen), hepatoprotective ( hepatically poisoning) and healing-regenerating . Adaptogens generally do not contain specific antidotes against specific chemicals but rather enhance the ability of cells to withstand oxidative and other stress and to stabilize chemical damage without triggering controlled cell death (apoptosis). Examples of specific chemoprotective effects:

The genius in chemoprotective effects is ginseng .

The chemoprotective effects do not form the nucleus of my interest in adaptogens, but in classical adaptogens I have encountered several publications mentioning the effect of ginseng on protecting the liver , kidneys and other internal organs that are often poisoned by poisoning. Administration of red ginseng at 250 and 500 mg / kg increased the liver regeneration rate by 20% ( Kwon2003ekr ) in the animal model. According to Shen2007peg and Ahn2011ieg protects ginseng from lung damage, according to Elsaieed2002thc, it protected the organism from the toxicity and teratogenicity of chromate ions. Ginseng had chemoprotective effects on tetrachloromethane damage (CCl 4 , Shim2010pai ). According to Wang2008icp , ginseng is chemopreventive to cytochrome P450.

Chemoprotective effects applicable to chemotherapy

Ginseng protects, according to available literature, healthy cells from apoptosis in chemotherapy without providing the same protection to the cancer cells that chemotherapy has to destroy. According to Shim2007cae , this supportive effect in chemotherapy can be attributed to the ginseng ginseng proteoglycan .

Other adaptogens with chemoprotective effects

Salidroside from another classical adaptogen, pink rosary , protected rat liver from damage by cholesterol poisoning ( Yang2016sao ).

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