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Dosage of ginseng to induce individual effects

(This page does not work yet, I hope it will be different in the future and will be used to calculate the required dosage of ginseng for the effects described.)

It is slowly becoming the standard that the quantitative data is provided by the research of the effects of various forms of ginseng and individual panaxosides. This gives the opportunity to calculate the appropriate dosing.

The problem of panaxosid variability and interactions

The situation complains that many physiological parameters have different panaxosides in opposition , so the summary gingular effect can not be easily estimated. Different forms of ginseng (fresh, white, red ...) are again significant differences in the amounts and proportions of the substances. Another source of variability is absorption, which modulates the efficacy of the patient's gut destroys and the activity of the bacteria living there and the modified panaxosides partially modified by the cleavage of the sugar residues. MUDr. Asian physicians are aware of this, and therefore require treatment of somewhat purified panaxosides or their prescribed mixtures, which are sometimes given by injection (such as infarctions). In addition to the rate of absorption, excretion, and transduction across the cell membrane, CNS effects are also a question of the rate of transfer across the blood-brain barrier.

At the current stage of the pharmacodynamic question I ignore and try to calculate for some effects the required single dose, assuming an immediate even distribution of the active substances in the soft tissues of the whole organism.

Content of ginsenosides in red ginseng

(An analysis of red ginseng ( gineng radix rubra ) provided by the TCE in Taipei.)

Panaxoside Mg / g Mg / g
Rb 1 1.3047 0.4070
Rb 2 0.9958 0.8214
Rc 1.1110 0.2263
Rd 1.7234 0.5505
Re 1.3340 2.8905
Rg 1 3.1327 2.9026
Rg 2 1.4886 2.3007
Overall 11.390 10.099

A single dose corresponding to a concentration of 10 μg / ml

Assuming that the human body contains 40 liters of water and provided the panaxosides are distributed evenly (due to their amphiphilic nature, the situation is close to reality), a single dose of red ginseng will be given the following concentration of ginsenoside 1 μg / ml:

Panaxoside Dose (g) Dose (g)
Rb 1 26.8 86.0
Rb 2 35.1 42.6
Rc 31.5 154.
Rd 20.3 0.5505
Re 26.2 2.8905
Rg 1 11.2 2.9026
Rg 2 23.5 2.3007
Overall 3.1 3.5

Interpretation with respect to individual effects

  • Effect pxsd. Rb 1 for the normalization of immune vascular parameters appeared at a dose of 10 μg / ml corresponding to 268 g of red ginseng ( he2007peg )
  • Effect pxsd. Rb 1 against aggressiveness occurred at 2.5 mg / kg, corresponding to a dose of more than 53.6 g of red ginseng ( yoshimura1988ace )
  • The effect of P. notoginseng panaxoside extract on endothelial proliferation and vessel regeneration was already at a dose of 0.1 μg / ml ( hong2009aes ), which would probably correspond to a dose of less than 0.3-1g of P. notoginseng ( estimated ).
  • ( Kwon2003ekr ) [ other ] Increased liver regeneration rate by 20% (experimental resection in a dog) at a dose of 250mg / kg ginseng radix rubra for 9 days (-1 to 7 due to surgery). At 80kg, this would be equivalent to 20g ginseng radix rubra per day.
  • ( Morisaki1995mae ) [ cardiovascular ] 100% increase in "capillary" growth rate was achieved with ginseng radix rubra 10μg / ml saponin, ie 60L soft tissues, 600mg ginseng radix rubra . An increase in growth rate of 300% was achieved by 100μg / ml, ie under the same assumptions as 6g ginseng radix rubra .

Further to processing

Rg 1 ( against hypertension : extends blood vessels kang1995gpg ) (promotes vascular growth of sengupta2004may ) (protects the neurons of liao2002neg ) (microglia relaxation wu2007deg ) (anti- stress kim2003iii ) (immunomodulation in favor of type 2 yu2005pgd )

Rg 2 (protects memory by anti-apoptotic action ( zhang2008pgg ), protects the brain against glutamate neurotoxicity ( li2007peg )) (microglia calming wu2007deg ) (possible immunomodulation for type 1 cho2002gfp )

Rb 1 (normalizes he2007peg immunity), (sedating effect of yoshimura1988ace ) (possibly immunomodulation in favor of type 2 cho2002gfp ) (expands blood vessels and protects them from arteriosclerosis he2007peg ) (suppresses leung2007gri vascular growth )

Rb 2 (anti-stress kim2003iii ) (microglia relaxation wu2007deg ) (anti-inflammatory, TNF-α in macrophages ( cho2001vie ) (possible immunomodulation for type 1 cho2002gfp )

Rc (normalizes stress (increases / decreases as needed) kim2003egs )

Rd (anti-stress kim2003iii ) (tranquilizing microglia wu2007deg , lin2007gra )

Re ( fertility zhang2006gif , zhang2007grp ) (calming microglia wu2007deg )

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