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I do not feel the effect of ginseng

Hello, I am very glad you are creating such an interesting website. I would like to ask if I'm doing something wrong in preparing ginseng stuffing. I bought the slices of Taiwanese 6-year-old ginseng TaiwanTCM Liang and started to prepare my infusion according to the enclosed instructions. For three days I made a 3-sliced root spice. I put the slices in a mug and pour it with boiling water and leave about 50 minutes to leaven. I do not feel like I'm feeling any change or some effects when using ginseng - more activity, less fatigue or something, so I would like to ask if I do not prepare poorly? Thank you. JJ

Dear JJ,

I did not want to write about the ginseng at all. But he can not be satisfied with his general understanding as a lifebuilder who heals everything and nothing. Ginseng and other adaptogens have specific, strong and long-lasting effects on the vascular, nervous and immune systems . These are not commonly known to our surgeons and manufacturers of synthetic drugs. In medical journals, obviously, rent articles (like Messina2006hsf ) appear that ginseng has "interactions" with drugs for thrombosis , diabetes , depression , etc. The aim of these articles is to conceal the fact that ginseng itself is a medicine against thrombosis and diabetes. This, of course, is a breach of scientific and citation ethics that we are not accustomed to here. I try to remedy this by providing a full view of the relevant professional literature.

And now to use ginseng ...

Ginseng is preparing properly. Be sure that if you measure the level of panaxosides in your blood or cerebrospinal fluid, you will see a slowly increasing concentration in the order of milligrams / liter. Be sure these panaxosides bind to the appropriate nuclear and non-nuclear receptors of the cells and act as they should.

The fact that you do not feel the effect can have several reasons:

1. Ginseng you take relatively short - effects come in three phases:

  • Short-term effects occur over the course of hours and days. They are caused by the direct interaction of panaxosides with non-nuclear receptors (receptors and enzymes in the membrane and the cytoplasm). This includes relaxing effect on blood vessels by allosteric boosting of NO synthase 3 , effect on non-nuclear receptors in the brain, or cell membrane stabilizing effect. These effects are directly proportional to the current level of panaxosides in the blood.
  • Medium-term effects occur over days and weeks. These effects are due to panaxoside interactions with nuclear receptors and subsequent gene expression change. They come with a delay of several days with respect to the panaxoside blood concentration curve because gene expression involves transcription of mRNA and translation of enzymes, which in humans lasts for many hours. It takes a few days to establish a new level of protein that is affected by these nuclear receptors. Thus, for example, the anti-inflammatory effect of ginseng works by limiting the expression of cycloxygenase via the NF-κB nuclear receptor, the effect on the glucocorticoid receptor, increased expression of NO synthase 3 in the blood vessels, etc. (Note: Panaxoside mixture in NO synthase 3 acts both as an allosteric as well as an increased expression Of this enzyme.)
  • Long-term effects occur over weeks and months. The human organism is in the constant process of rebuilding, and when some parameters of cell behavior change, it may take many months for it to be reflected in the re-engineering of tissue systems. Ginseng may begin to improve capillary growth some days after you start taking it, but it takes months to improve your blood vessel organs. Although ginseng suppresses inflammation of the joints , it takes a long time before the damaged tissue recovers. Although ginseng reassures microglia in the brain and macrophages on the internal walls of the vessels, it takes a long time to do so by reducing neuronal death and significantly slowing down atherosclerosis .

2. A dose of 3 slices per day may still not be high enough for subjective observation

Together with an effect on erection , the psychotropic effects are practically the only ones that you have the chance to notice for a short time with ginseng. In the case of ginseng, it is actually possible to talk about happiness - they are adaptogens, such as glans , for which nothing can be learned subjectively.

However, the dose of 3 slices may not be high enough to distinguish ginseng from natural mood swings and performance. You know, many people feel the doses of more than 3 slices too high, so I did not want to recommend larger doses. To tell the truth, as far as I am concerned, I do not feel anything with my 90kg live weight at a dose of 3 slices. In a dose of 15 slices, the effects (for me) are not overlooked, I recommend a high dose but I did not allow.

3. Ginseng is an adaptogen ...

The third reason is that ginseng as an adaptogen should not actually work or function in people outside the burden by definition . Its effect on the hypothalamic-pituitary (ie stress) axis will be especially evident when you are under stress. After all, ginseng is not a panacea or a miracle. TCM physicians tend to say that even ginseng is not for everyone. Perhaps you are perfectly healthy, you live in a fairly pure environment and you do not need ginseng. If this is the case, keep a healthy lifestyle and trumps to save on the period of stress.

Regards,
-boris-

| 12.10.2010

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