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Cholinergic effects (memory protection)

Cholinergic model of memory impairment

Like depression, it can roughly be linked to serotonin and Parkinsonism with dopamine, the central acetylcholine system is associated with memory. A standard model of memory impairment in the research is the administration of a cholinergic antagonist of scopolamine. Substances whose memory effect is demonstrated on the model of scopolamine damage usually at least slightly help with the most common memory-damaging disease - Alzheimer's disease - although its real cause is the physical destruction of neurons by β-amyloid accumulation. The effects of their content on the central acetylcholine receptors and the biological pathways associated with them are therefore investigated in adapogenic compounds with a protective effect on memory and nootropic effect.

Cholinergic Effects of Adaptogens - Impact on Memory

Many adaptogens have a protective effect on the CNS . This has also led to research into their impact on memory protection, which is linked to the cholinergic system.

Ginseng right to improve memory

Genus Genus ( Nitta1995pge ), as well as American ginseng ( Sloley1999age ), modify scopolamine disrupted learning in rats. This effect was attributed specifically to ginsenoside Rg1 ( Yamaguchi1995egi ) and ginsenoside Rb1 ( Benishin1991egr ), which also facilitates the excretion of acetylcholine from the hippocampus. According to Salim1997grr, ginsenoside Rb1 also expresses the expression of acetylcholine transfer enzymes and transporters - choline acetyl transferase mRNA and the like. Inconsistent message about gssd. Rb 1 handles Yamaguchi1996egi , according to which memory protects gssd. Rg 1 and Re , but not gssd Rb 1 , R d , F 2 , R f , Rh 1 or 20-O-Glu-PPD . Gssd Rg 2 , Rg 3 , Compound K and protopanaxatriol aglycone reversibly block the neuronal acetylcholine nicotinic? 3? 4 receptor. ( Lee2003deb , Jeong2004sgr , Lee2009rlr ).

Other adaptogens

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