What are Steroid Receptors?
The effect of panaxosides on steroid receptors and pathways
Ginseng saponins are steroidal in nature and it is not surprising that they affect the steroid receptors of mammalian cells (estrogenic, anogenic, glucocorticoid receptor, etc.). However, there is no coherent conclusion. Panaxosides, by acting on the steroid receptors, tend to produce effects that are not related in the consciousness of the people - neuroprotective, cardiovascular and the like. Ginseng does not interfere with the balance of sex hormones. For example, its effect on erection is not the result of some hormonal action, but the activation of nitric oxide synthesis in the blood vessels . The following examples of specific interactions are not exhaustive, the panaxoside publications on this topic are about ten times more.
- Ginsenoside Rg 1 , but not its aglycon, is a potent phytoestrogen. However, gssd. Rg1 does not directly affect the estrogen receptor. ( Chan2002eag )
- Ginsenoside Rg 1 acts on estrogen receptors and pathways and affects the immune system . ( Lau2008gre , Chan2002eag , Lu2008grp )
- Ginsenoside Rb1 acts on the estrogen receptor and thus protects the neurons from apoptosis. ( Hashimoto2012grp )
- Ginsenoside Rb 1 by acting on the β estrogen receptor inhibits angiogenesis . ( Leung2007gri )
- Ginsenoside Rh 1 acts on the estrogen receptor. ( Lee2003gcg )
- Ginsenoside Re acts on the androgen receptor, estrogen receptor α and progesterone receptor. As a result, it facilitates the activation of endothelial NO synthase .
- Ginsenoside Rb1 acts on the androgen receptor and activates vascular NO synthase. ( Yu2007spn )
- Ginsenoside Rg 3 acts on the androgen receptor and inhibits the division of prostate tumor cells in vitro . ( Liu2000aeg )
The concept of adaptogen is theoretically defined in relation to stress . Practically, in the ginseng modelogen adaptogen it appears that its content acts directly on the glucocorticoid receptor. The main glucocorticoid in humans is the stress hormone cortisol.