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Steroid receptors and pathways

What are Steroid Receptors?

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The effect of panaxosides on steroid receptors and pathways

Ginseng saponins are steroidal in nature and it is not surprising that they affect the steroid receptors of mammalian cells (estrogenic, anogenic, glucocorticoid receptor, etc.). However, there is no coherent conclusion. Panaxosides, by acting on the steroid receptors, tend to produce effects that are not related in the consciousness of the people - neuroprotective, cardiovascular and the like. Ginseng does not interfere with the balance of sex hormones. For example, its effect on erection is not the result of some hormonal action, but the activation of nitric oxide synthesis in the blood vessels . The following examples of specific interactions are not exhaustive, the panaxoside publications on this topic are about ten times more.

Estrogen receptor

Androgen receptor

Glucocorticoid receptor

The concept of adaptogen is theoretically defined in relation to stress . Practically, in the ginseng modelogen adaptogen it appears that its content acts directly on the glucocorticoid receptor. The main glucocorticoid in humans is the stress hormone cortisol.

  • Ginsenoside Rg1 acts on the glucocorticoid receptor. ( Kang1994gri , Cheung2011gia )
  • Ginsenoside Re acts on the glucocorticoid receptor in endothelial cells and phosphorylation of endothelial NO synthase facilitates the production of nitric oxide. ( Leung2007neg )

| 24.10.2010