Ginseng is contraindicated in acute bacterial diseases because its inhibitory effect on inflammation and the tendency to boost the type 1 immune response (antiviral and anticancer) is at the expense of Type 2 (antibacterial) response. Ginseng would reduce the sharpness of the immune reaction against acute bacterial infection. For purely safety reasons, I also recommend that ginseng not be used in the first trimester of pregnancy . In later stages of pregnancy, ginseng is no problem .
Other ginseng contraindications have virtually no contraindications
There is a superstition that ginseng should not be taken at a higher pressure. This superstition is completely false. Ginseng in hypertension is not contraindicated, on the contrary, it is very appropriate ( Han1998erg , Sung2000erg , Jovanovski2014erk ). Ginseng is also excellent for elderly people and people suffering from civilization diseases: atherosclerosis , diabetes , allergies and autoimmune diseases . Ginseng has beneficial effects especially in cardia ( Jia2012cgm ).
Ginseng has virtually no side effects
Ginseng is an almost perfect adaptogen and as such has virtually no side effects . However, since some people can not imagine a cure without undesirable effects, ginseng is thinking about it. Thus, we find that the adverse effects of ginseng include increased blood pressure, nervousness, insomnia, skin rash, and diarrhea that were found in the article Siegel1979gas in JAMA magazine 1979 and Chen1981eas in Journal of Traditional Chinese Medicine for TCM ") collectively called ginseng abuse syndrome - ginseng overdose syndrome. The 1979 article was based on a questionnaire that filled 133 patients with a history of ginseng use. There are no experimental studies to confirm these ginseng side effects. Instead there are reports of individual patients whose health condition worsened at the time they took ginseng ( Paik2015rcp ). Of course, these cases do not prove, because even those who use adaptogens sometimes get worse. However, the EU used the "ginseng overdose syndrome" to introduce a maximum dose of 2 g / day of ginseng, which is sometimes inadequate.
It is good to examine the adverse effects of ginseng because many patients rely on its safety. However, previous studies and experience of the TCM show that ginseng does not have the above- mentioned side effects ( Paik2015rcp ). It can certainly be rejected, for example, the claim that ginseng increases blood pressure (in fact it acts against hypertension) or causes a skin rash (in fact, it has an allergy). The genius - even though he is mentally encouraging - does not cause insomnia . Ginseng is not caffeine. Ginseng itself does not interfere with the cycle of sleep and waking has been shown on animals ( Lee1990cip , Huong1998aem ) and on humans ( Han2013erg ).
Unreliable sources describing the fictional ginseng side effects are confusing for other researchers. On the Czech Internet is a regrettable case an article about ginseng , which is signed by doc. RNDr. Lubomír Opletal, CSc., Containing a long section on the adverse effects of ginseng. With doc. I communicated about this and I told him that the article once wrote for the website Ordinace.cz and drew the side effects from the above-mentioned sources. Doc. Opletal had no information on any further studies confirming the toxicity of ginseng. However, it would be necessary to co-operate with the publisher, as doc. Opletal no longer owns the right to that article.
Ginseng practically does not have drug interactions
Ginseng is harmless and practically does not have a toxic dose. Experimental studies have concluded that ginseng drug interactions are virtually non-existent ( Ramanathan2016pdi ). But the ginseng drug interactions are still circulating around the world. In my opinion, those who want to challenge this ancient drug as part of a broader anti-propaganda propaganda are spreading. When I look at the unfortunate article of Messina2006hsf , published in a major medical magazine and 100% based on speculation, or a Miller1998hms article, no word other than anti-propaganda propaganda impresses me (see also Fughberman1999hms ). From a commercial point of view, ginseng competes with Paracelsus drugs , while it is non-toxic and adaptive . On the lists of fictitious ginseng interactions, warfarin and anticoagulants in general, hypertensive drugs, diuretics, digoxin, steroids and estrogens, insulin and antidiabetic agents and psychopharmaceuticals (phenelzine and other monoamine oxidase blockers) appear.
- Anticoagulants : Frequently mentioned ginseng interaction with warfarin does not exist ( Zhu1999pig , Vaes2000iww , Lee2010ibw ).
- Amlodipine and other anti-hypertensive drugs : Interaction of ginseng with amlodipine does not exist ( Ryu2014npi ). Even with other drugs against hypertension, there is no interaction with ginseng that should be mentioned ( Ramanathan2016pdi ). Again, ginseng itself has an effect against hypertension confirmed in animals ( Chow1976psc , Jeon2000ekr ) and human patients ( Han1998erg , Sung2000erg , Jovanovski2014erk ). More specifically, the effect of ginseng on blood pressure is adaptive and stabilizing.
- Digoxin: Interaction of ginseng with digoxin does not exist ( Ramanathan2016pdi ). This interaction refers to the Chen2012him and Shi2012diw reports , but its experimental evidence does not exist. As in previous cases, ginseng alone is a beneficial drug in cardiac patients.
- Insulin and antidiabetic medicines : Ginseng interactions with antidiabetic medicines have not been reported ( Ramanathan 2016pdi ). Ginseng actually lowers blood sugar levels in diabetics, because it is one of the most effective anti-diabetic agents.
Ginseng is harmless and safe
Ginseng does not have a toxic dose. It can be consumed as if it were a normal food. It can also be used as a vegetable soup. Even in doses of tens of grams, ginseng is harmless ( Coon2002pgs , Kitts2000esg , Seely2008sep ). The purified panaxosides have a toxic dose but are extremely high ( Kaku1975css ).
Until recently, anyone claimed that ginseng is completely ineffective, that it is basically placebo. Today, when its effectiveness is scientifically indisputable, it would be a mistake to let go of lists of fictional interactions and side effects. Compared to Paracelsus , ginseng is extremely safe .