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Neurological Problems (Paroxysmal Dystonia)

... I have a very similar epilepsy throughout my life (30 years), only shorter, often very intense: 1-2 minutes, about 200 a day, very fluctuating. Diagnosed as paroxysmal dystonia - the main factor of stress. I've been using neurological medications all my life, but if I did not try to "optimize" ... I would probably be dead because this is not medicine. I've tried everything, it's always overwhelmed by extreme stress, I can not avoid how much I live in a sick family, but I try to take steps very active to eliminate the negative effects of my family on me ... about two years ago I tried Chinese Tea (the best are pi lo chun and snow buds ) that I still order and very well makes me ginseng. What does not hold "medicine", ginseng really replaces: -) ... I want to ask what it contains, respectively. What mechanism could be used for Chinese tea, because it really can do it for 200 or more, almost continuous convulsions, "cool 50". Morning convulsion behind the cramps - a cup of tea and "comfort" ... When I told the doctors to see what it contained, so did not say anything, while we tried literally abnormal drugs - for parkisonics and so on. That's why I want to ask you, as an expert of circumstances, if you find anything interesting about you? Thank you very much, Milan.

Dear Milan,

Coordination of movement is a challenging task for a human-sized organism because it is at the limit of the ability of our nervous hardware. With fiber lengths often exceeding 1m, tens of milliseconds are needed for signal transmission and hundreds of other motion program processing. We do not have time to think about whether to use biceps or triceps, we just want the result of the movement and the hand is doing it "by itself". Before the spinal cord motor neuron gives the command of the muscle, tens and hundreds of cerebral systems work in the preparation of motion in the cerebral cortex, basal ganglia and cerebellum. I would compare it to the orchestra whose command is our will. When the orchestra plays a solo or a general pause, all players must be silent. This is not the case for people affected by dyskinesia - the suppression of the activity of one or the other automatic system is incomplete and there are unwanted movements.

Your symptom description is not detailed enough - the causes may be hundreds. It is more than clear that physicians do not even have the aetiology of your spasms or insights, but they use their standard methods. The patient easily comes to GABA agonists : Diazepam, Rohypnol, Zolpidem, Valium ... They have a thousand names, but only one effect - they dampen the brain through the GABA receptors , the most brain receptors . My position on them is clear - if possible, not take it . This is killing the fleas with a hammer. You have also been given medication for Parkinsonian and "abnormal medication," which will surely be medicines for schizophrenics or people with hyperactivity. Doppler Modulators? They are popular because they engage in schizophrenia and some parkinsonism . But I have the feeling that in your case the dopamine receptors will be near, but still beside.

You write that you are doing well the gourd and ginger . An effective tea-making substance is, like coffee, caffeine . In addition, the teaspoon contains its own GABA agonist - teanin. Inhibitory GABA receptors are the most abundant brain receptor because the major interaction between brain neurons is inhibition. Thus if we block the first neuron in the neural path, the activity of the second neuron will increase, the third will decrease again, etc. If the neural path is a circle or a network, the situation is even more complicated. You ask me for a mechanism, but science can not answer. Although we know that caffeine acts on adenosine receptors and ginseng on many different receptors, we are not able to derive this information from the overall nervous effect.

So let's summarize: We scientists do not know anything at all and you have to help yourself how you know. The only thing I can recommend is what you already do - to try your own, what helps you, and then stick to it. I'm glad your ginseng helps - and in other cases I was surprised by his potential for neurological problems. You are doing well that you are testing different types - a small change in the panaxoside ratio may have a big impact on the overall effect due to their mutual antagonism. You can also try a ginseng flower or American ginseng. As far as other options are concerned, it is difficult to advise. In my place, I would try out traditional psychoactive substances in your place. You do not know if you smoke. If not, try small medication nicotine or medicinal cannabis (best to eat because the smoke is harmful to the lungs). Try to try and try just try if they do not take you by chance. I would also recommend to try to extract the coca leaves, which, unlike snuff cocaine, are harmless and little addictive, but if the whole plant was not forbidden in our country. I would also replace commercial GABA agonists (soothing medicines) with the Pacific kava kava ( Piper methysticum ), which also suffers from unnecessary authorization problems in the EU. From what grows in Central Europe, you can try the lute, St. John's wort, the nerve regeneration of the royal jelly, but the miracles are not.

-boris-

Hi, thank you for the professional answer, I do not smoke, I do not drink, I'm eating out, the main factor is stress, I know where it comes from, it's the fact that I have a shifted intimate zone, so I need my "home" I live in a "sick family". To the spasms themselves: mainly tea, so I ask what can cause up to 50 or more percent drop (sometimes) cramps on the pi-lo-chun cup, respectively. Snow buds. On the contrary, when I drink more than 2 doses a day (eg 3, 4 cups, depending on the watering), it causes cramps, but "classic" like a typical cramp in the calf, and then I can paradoxically get "my". As for ginseng, I tried TaiwanTCM Liang ginseng , generally for all medicines, teas, and so on. I respond sensitively, and I know a few hours after I know what I've been doing, I tried half a slice of ginseng, today all, all is too much ... Ginseng of a lower quality (dried root) poured with boiling water with the addition of marigold, lengthened about 10 minutes and then again Poured for about 2-3 minutes ... also doing its own. Mainly ginseng in the sense of cushioning effects of neurological drugs, even I would do according to the doctor could take 5 times the dose ... :-) but I would not write with you ... From these two doses I can say that the ginseng 6years is stronger, Try and compare and give info. Nice day, Milan.

Dear Milan,

We have found. You are endowed with extrovert, and I will be willing to respond.

Let me repeat that I am very pleased with your interest and I am also delighted that the ginseng is benefiting. It is a pleasure for me, because today, medicine still emphasizes synthetic drugs, which are becoming more and more expensive, while ginseng still have doubts about its effectiveness as such. In spite of the relatively high price compared to conventional herbs, ginseng panaxosides are considerably cheaper than synthetic active ingredients - when you take a well-dried red ginseng root , up to 20% of its weight is pure active ingredients.

As far as your other questions are concerned, they basically coincide with those you put in my first letter. You will find answers to them in the first answer, but I can give them more shovels. I do not know if we have a good understanding of smoking. My suggestion was just to try nicotine as a medicine, not necessarily by inhalation of smoke. Nicotine is in most cases harmful, but in some cases it helps. These include some neurological problems related to dopamine pathways. Nicotine I mention purely because most doctors will not remember him as a drug. Oral, transcutaneous, or safe inhalation can be given by the so-called electric cigarette - a nicotine smoke inhaler.

I have responded to problems with your family in silence - the need for moving is clear, financial problems are now the norm in Central Europe. This problem has no easy solution. I did not want to discuss your life. When Captain Scott returned from the South Pole a hundred years ago, his polar night and snow storm reached temperatures of -40 ° C. There were supplies in the expedition, and their legs were frozen. They considered suicide, but they agreed to perish naturally on the march. But they did something else - they camped, climbed into their sleeping bags and gradually made their way. Scott was the only one after a week's wait for better weather to try to get up - found him frozen in his sleeping bag. Mr. Milano, if you can not do anything, unpack your sleeping bag. Or adapt as Smoljak and Svěrák sing.

I also silenced the neurophysiological nature of the tea plant's action on your dyskinesia, as I was ashamed to crawl the hypothesis about what not to explain even specialists yet. But to prove that I'm bluffing, I draw a picture of involvement of the dopamine pathway from the recent speculative publication ( Lisman2008cfu , pictured right) and derived from my own speculative suggestion of the action of teaspoon caffeine and teanin on this path (pictured below). For example, you may notice that my caffeine pattern acts actively on the P2X receptors of inhibitory interneurons (and potentially the entire chain of inhibitory interneurons), as well as on the pyramidal cells themselves, which represent the data output of the cerebral cortex. It can be imagined that low-dose tea-based caffeine activates not only the pyramidal cell, but also inhibitory interneuron, which however suppresses its increased activity by the pyramidal cell so that it is even less active than if there were no caffeine in the brain, so your cramps weaken . At high caffeine concentrations, however, activation of the pyramidal cell is so strong that even the increased buffering effect of interneurons does not inhibit it and the convulsions become stronger. But that is only one of the dozens of possible explanations. Similarly, teanine can be considered, which in turn increases the level of inhibitory neurotransmitter GABA. Whether you are the active ingredient of caffeine or teanin you can find out by trying coffee. If you do not get coffee, but tea does, tea-specific substances are key to you. Then it would be understandable that you observe the differences between tea (teas). In particular, the so-called white tea you praise should have a higher ratio of teanine to caffeine. The highest amount of teanin has said Japanese tea gyokuro.

On the Lisman article diagram (top right), you can still notice the letters "ACh" on the square blue-green color neuron. They mean acetylcholine, and just the central acetylcholine receptors act on the nicotine I talked about earlier.

My dopamine schema

I hope my mechanistic speculation was not entirely incomprehensible. I knew a neurophysiologist who suffered from dyskinesia like yours. He was a very intelligent person who had apparently Pasteur's motivation to study, and with respect to writing this more detailed answer.

-boris-

| 19.1.2009

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