Dear visitor, this is a machine-translated article. It makes perfect sense in its original language (Czech), and is fully backed by independent scientific literature. The translation, though, is far from perfect and takes patience and imagination, if you decide to read it.

Drobečková navigace

88. ginsenoside Rg1

ginsenoside Rg 1

It is a damaran, protopanaxatriol panaxoside (6-Glc, 20 (S) -Glc PPT).

ginsenoside Rg1

  • It causes an endothelial dependent relaxation in vitro of the aortic ring preparation in rats. ( Kang1995gpg )
  • It regulates scopolamine disturbed learning in rats. ( Yamaguchi1995egi )
  • In mice subjected to stressed immobilization, the level of plasma interleukin-6 decreases. It also in vitro reduces the release of IL-6 from macrophages by epinephrine / norepinephrine. ( Kim2003iii )
  • It has antidepressant activity and improved nerve regeneration in mice at a dose of 20mg / kg. ( Jiang2012aeg )
  • Pxsd. Rg 1 and Re strongly suppress the production of TNF-α and NO microglia-activated lipopolysaccharides. ( Wu2007deg )
  • It had a protective effect on the lungs when attempting to treat glutamate. ( Shen2007peg )
  • Gssd. Rg 1 and Rb 1 had a protective effect on spinal neurons in vitro. ( Liao2002neg )
  • It suppressed T-cell proliferation (CD8 +) of mouse spleen with an IC 50 of 64.7 μM. ( Cho2002gfp )
  • It supports the production of IL-4 and the maturation of T H 2 lymphocytes ( Lee2004gre ).
  • Gssd. Rg 1 as well as gssd. F1 increase the binding of NF-κB transcription factor to DNA in the culture of mouse splenocytes. They also increase mRNA transcription factor GATA3 and type 2 cytokines controlled by it (IL-4 in splenocytes and IL-12 in macrophages). The highest effect on IL-4 and IL-12 was at concentrations of 5 and 10μM, at higher concentrations, the effect was reduced to 50μM again almost disappearing. ( Yu2005pgd )
  • Gssd. Rg 1 tended to increase the aggression of mouse mice ( Yoshimura1988ace ). In contrast, gssd. Rb 1 , as well as total ginseng extract, suppressed aggression.
  • Supports angiogenesis. ( Sengupta2004may )
  • Mixed with gssd. Rb 1 , at 48 mg / day infusion, significantly decreased the expression of PPARγ receptors in macrophages of diabetics. ( Ni2010sgp )
  • Blocks the effect of inflammatory factor TNF-α on protein expression in human umbilical vein endothelial cells. Among other things, it increases the expression of NO synthase and the production of NO, which acts contrary to TNF-α. ( Ma2006pae )
  • After irradiation, it protects cells from apoptosis, most of all panaxosides. ( Lee2006ivr )
  • In the mouse model of arthritis, it protected the joints by inhibiting the differentiation and maturation of osteoclasts. ( Gu2014smp )

| 9.3.2009