Dear visitor, this is a machine-translated article. It makes perfect sense in its original language (Czech), and is fully backed by independent scientific literature. The translation, though, is far from perfect and takes patience and imagination, if you decide to read it.

Drobečková navigace

5. ginsenoside Rb1

Ginsenoside Rb 1

It is a damaran, protopanaxadiol panaxoside:

Ginsenoside Rb1

R 1 = -Glc 2-1 Glc
R 2 = -Glc 6-1 Glc

  • It did not have a relaxing effect on the aortic ring preparation in rats. ( Kang1995gpg )
  • It works against memory impairment with scopolamine. ( Benishin1991egr )
  • Does not cause memory impairment with scopolamine. ( Yamaguchi1995egi )
  • Increases the secretion of acetylcholine from hippocampal cuttings. ( Benishin1991egr )
  • It increases the choline import into synapses and increases the expression of enzymes and proteins of acetylcholine metabolism over a period of time (over 3 days). ( Benishin1992agr )
  • Gssd. Rb1 selectively enhances the expression of choline acetyl transferase mRNA, TrkA neurotrophin receptor and nerve growth factor (NGF). ( Salim1997grr )
  • Prevents increased levels of the stress indicator of putrescine in the CNS under immobilization stress. ( Lee2006aeg )
  • Gssd. Rb 1 and, in particular, its metabolite, Compound K , have the ability to inhibit the production of NO and prostaglandin E2 in macrophages (RAW264.7) activated lipopolysaccharides by limiting the expression of NO synthase 2 (NOS2 gene) and cycloxygenase 2 (PTGS2 gene) as well as blocking their transcription factor NF-κB. ( Park2005ieg )
  • Gssd. Rb 1 and Rg 1 had a protective effect on spinal neurons in vitro. ( Liao2002neg )
  • Gssd. Rb 1 and Rb 2 suppressed TNF-α production in both mouse and human macrophage stimulated lipopolysaccharides with an IC 50 ~ 50 or ~ 25 μM. ( Cho2001vie )
  • At a concentration of about 100 μM, the proliferation of mitogens stimulated by T H (CD4 +) and B lymphocytes significantly increased. ( Cho2002gfp )
  • The 2.5 mg / kg Rb 1 dose suppressed aggression of mouse mice, while pxsd. Rg 1 tended to increase it. The effect of the gross ginseng extract was on the downside of aggression. ( Yoshimura1988ace )
  • It reduces endothelial damage by LDL (low density lipoprotein) indicated by lactate dehydrogenase (LDH) levels. At 10 μg / ml, normalized decreased expression of endothelial NO synthase (NOS3, eNOS) and tissue plasminogen activator (PLAT, t-PA) and increased expression and increased expression of the SERPINE1 gene (PAI-1, plasminogen activator inhibitor type 1). At 1 μg / ml this standardization does not occur. ( He2007peg )
  • Gssd. Rb 1 by acting on the estrogen receptor β and subsequent induction of the PERF (pigmented epithelium-derived factor) gene suppressed angiogenesis on the human umbilical vein endothelial cell experimental model. Leung2007gri
  • Mixed with gssd. Rg 1 , at 48 mg / day infusion, significantly decreased the expression of PPARγ receptors in macrophages of diabetics. ( Ni2010sgp )
  • Its effect against experimental arthritis by blocking TNF-α has been observed. ( Kim2007aeg )
  • In a dose of 0.25mg / kg (IP injection), but not at higher doses, gssd. Rb 1 significantly increased the performance of the learned distinguished task in chickens. At doses up to 5 mg / kg gssd, Rb 1 proportionally reduced the stress of isolation in chickens. ( Churchill2002npg )
  • Gssd. Rb 1 decreased Ca2 + concentration in rat neurons, and also increased FeS04-cysteine - deficient synaptosomal membrane fluidity. ( Jiang1996mag )
  • Gssd. Rb 1 increased the activity of Na / K ATPase and Ca / Mg ATPase in neurons. ( Jiang1996mag )
  • Gssd. Rb 1 decreased Na / K activity in neurons incompatibly with an IC 50 of 6.3 μM, while the inhibitory effect of gssd. Rg 1 is much smaller. ( Cao1990ieg )

| 10.3.2009