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20-O-glucosyl-PPD (Compound K)

20-O-glucosyl-protopanaxadiol, compound K

It is the main product of bacterial hydrolysis of panaxosides that occurs in the intestine:


R1 = -H
R2 = -Glc

  • In stressed mice, plasma cortisol is reduced. ( Kim2003iii )
  • It has all the panaxosides the strongest effect against the allergic reaction . In experimental skin anaphylaxis (PCA), 99% suppressed an allergic reaction at 25 mg / kg intraperitoneally and 98% suppressed orally. At 10 mg / kg, the suppression of the allergic reaction was 44%. The strong anti-allergic effect of Compound K has been demonstrated in other in vitro tests. It is not a histamine receptor antagonist. ( Choo2003aag )
  • It protected chondrocytes in rheumatoid arthritis models in vitro ( Choi2013jec ) and the rat model ( Chen2014gmc ).
  • It inhibited angiogenesis by regulating sphingosine kinase 1 detected in an in vitro assay on human vascular endothelial cells. ( Shin2014gci )
  • It inhibited angiogenesis by inhibiting MAP kinase and protein kinase B (PKB). ( Jeong2010cib )
  • It has shown an anti-inflammatory effect in vivo in experimental animal inflammation. ( Lee2005ape , Shin2005egr )
  • It has shown an anti-inflammatory effect in vitro by reducing the production of NO and prostaglandin E2 in activated macrophages by inhibiting the transcription factor NF-κB. ( Park2005ieg )
  • It acts inhibitory on the neuronal form of nicotinic acetylcholine receptors (α3β4). ( Lee2003deb )
  • In addition to the above, anti-diabetic, cytoprotective, neuroprotective and hepatoprotective effects were detected for compound K. ( Yang2015rbp )

| 10.3.2009