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Inflammation, and chronic inflammation

What is inflammation

Inflammation is caused by damage to tissue and conventional medicine is characterized by four attributes:

  • calor - heat, fever inflamed body parts
  • dolor - pain
  • rubor - redness of inflamed areas of the body
  • Tumor - swelling

Damaged cells release the chemical signaling molecules (histamine and prostaglandin) which lead to dilation of capillaries inflamed body part. This causes an increase in temperature and redness of the affected part. Inflammatory signaling molecules have two additional effects:

  1. Summoning immune cells (leukocytes) to the inflamed body part.
  2. Cause increased pain site of inflammation.

Leukocytes penetrate the inflamed body part through its ability to transition (diapedese) wall of the blood capillaries. Increased pain perception is reflected more painful stimuli (hyperalgesia) and perception normally painless stimuli (eg. Touch) as painful (allodynia).

Chronic inflammation and pain

Inflammatory pain is normally effective. Accompanied by inflammation because we indulge in the injured organ peace. For example, in muscles and joints after exertion appears inflammation and pain that tells us how long we rest. Here, it is not necessary to dampen naturally subside once tired muscles and joints regenerate. The antithesis of effective pain is ineffective pain in chronic inflammation that persists without progression to cure. Such pain is important to dampen analgesics.

Anti-inflammatory effect is typical for adaptogens

For reasons which I gave in the article about the pain we have between the classic multiple plants adaptogens with effect against chronic inflammation. They thrive in both inflammation due to normal wear and effortlessly , and chronic autoimmune and inflammatory. Chronic inflammation is often a deeper point to an autoimmune disorder of the immune system. In autoimmune disorders (eg. Rheumatoid arthritis ), doctors often do not know advice and adaptogens are offering welcome relief.

Ginseng inhibits chronic inflammation and pain

For many species panaxosidů ginseng (Panax ginseng) was demonstrated by their anti-inflammatory and antiallergic effect. This is coupled to the immunomodulatory and antitumor effects of ginseng.

Panaxosidy protects against tissue inflammation and suppress the excessive production of NO

Several panaxosidů to demonstrate their ability to reduce gene expression of NO synthase 2 and cyclooxygenase 2 and inhibit the transcription factor NF-kB. Among them gssd. Rh 1 and Rh 2 ( Park1996gri , Park2003aag ), which also block the outpouring of histamine and development of allergic reactions better than the standard drug disodium chromoglikát. Furthermore, it is gssd. 20 (S) -PPT ( Oh2004sog ) alone panaxatriol therefore, a metabolite of gssd. Rh 1 and Rg 1 . Also gssd. Rb 1 and particularly its metabolite compound K ( Park2005ieg ) strongly reduce reduce the production of NO and prostaglandin E2 in activated macrophages by inhibiting transcription factor NF-κΒ. Sorry for the reduced clarity of some of these sentences.

  • Reducing the expression of inducible cyclooxygenase and nitric oxide synthase inhibition of transcription factor NF-kB. ( Oh2004sog )
  • The same effect was to compound K showed an experimental inflammation induced by the phorbol ester karcinogenenem of croton oil. ( Lee2005ape )
  • P. notoginseng had an inhibitory effect on NO synthase, cyclooxygenase 2 and inflammation. ( Jin2007iep )
  • Red Ginseng counteracts chronic inflammation of the stomach and its complications - stomach cancer . ( Kim2010pfc )
  • Ginsenoside Rb 1 and compound A are effective in a mouse model of chronic dermatitis. ( Shin2005egr )
  • Gssd. Rc acts against gastritis, hepatitis and arthritis. ( Yu2016grf )
  • Pseudo-ginsenoside RP1 suppress inflammation by inhibiting NF-kB. ( Kim2009grg )
  • P. notoginseng saponins suppress acute inflammation in a rat model ( Li1999aet )
  • Gssd. Rb 1 and particularly its metabolite compound K , can also block the transcription factor NF-κΒ and strongly reduces the activity of NOS2 and production of prostaglandin E2 in activated macrophages . ( Park2005ieg )

Although ginseng counteracts inflammation, not immunosuppressive

Ginseng has a complex immune system effects. The overall effect of ginseng is more of an anti-inflammatory and is probably due to ginseng in acute bacterial disease traditionally contraindicated. Push-pull effect, so typical of ginseng, but also evident in his work on immunity in general and inducible NO synthase 2 in particular. It turns out that ginseng polysaccharides (α 1-> 6 glucopyranoside and β 2> fructofuranoside 6, the molar ratio of 5: 2) have the ability to activity "military" NOS2 increase. ( Lim2002aep ) Despite its anti-inflammatory effect, therefore, ginseng does not seem to have an immunosuppressive effect.

Other adaptogens antiinflammatory

Inflammatory adaptogens are multiple. Here, for now I offer a link to a clear scientific article about the plants with anti-inflammatory effect, Mobasheri2012iih who mentions them in large quantities.

  • Ginger true of miraculous Ginger family (Zingiberaceae) has extensive anti-inflammatory ( Grzanna2005ghm ).
  • Kurkumovník long also among ginger glaze, and has a strong effect against inflammation and pain ( Bright2007cad , Lakhan2015zep ).
  • Traditionally in our use of willow bark ( Vlachojannis2009sre ), the main active ingredient is known as aspirin.
  • Extract of some species of pine is also one of Europe's traditional medicines. Today it is available in the market patented extract of maritime pine Pycnogenol, which has activity against cell stress and inflammation ( Liu2016paa , Kolacek2013enp , Khan2013pmn , Fan2015par and others). Similar properties has also probably Kosodrevinová extract (silica / oil).
  • Hailing snodárná has significant anti-inflammatory effects ( Rasool2006irw , Grover2010ina ) inhibition of transcription factor NF-kB ( Grover2010ina ).
  • Lingzhi mushroom has documented anti-inflammatory effects ( Hong2004egl ). Taiwanese research team examined on cells on human aortic smooth muscle of the damaged vessel and artificial mouse anti-inflammatory effect, particularly by reducing ICAM-1 expression and the transcription factor NF-kB.

| 19.6.2016