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Chemical burden (for example, chemotherapy)

The concept of adaptogen is related to the concept of stress, which in its broad meaning refers to any burden on the body. While physically and psychologically , or even in the radiation load , we are intuitively well aware of what is involved, chemical burden is a less common term that literally includes all the poisons and extraneous chemicals that act in the environment on the organism. Adaptogens protecting against chemical burden are called chemoprotective .

Chemoprotective properties of adaptogens

The chemoprotective effects of adaptogens do not form a distinct category, but according to a particular kind of poison, they are combined with antioxidant (oxidant), neuroprotective (neurotoxin), anti-tumor (carcinogen), hepatoprotective (hepatically poisoning) and healing-regenerating . Adaptogens generally do not contain specific antidotes against specific chemicals, but rather enhance the ability of cells to resist oxidative and other stress and to stabilize chemical damage without triggering controlled cell death (apoptosis).

Examples of specific chemoprotective effects

The chemoprotective effects do not form the nucleus of my interest in adaptogens, but in classical adaptogens I came across several publications mentioning its effect on the protection of liver , kidneys and other internal organs that are often poisoned by poisoning:

The chemoprotective agent is ginseng . Administration of red ginseng at 250 and 500mg / kg increased the liver regeneration rate by 20% ( Kwon2003ekr ) in the animal model. According to Shen2007peg and Ahn2011ieg protects ginseng from lung damage, according to Elsaieed2002thc, it protected the organism from the toxicity and teratogenicity of chromate ions. Ginseng had chemoprotective effects on tetrachloromethane (CCl4, Shim2010pai ). According to Wang2008icp , ginseng is chemopreventive to cytochrome P450.

Salidroside from another classical adaptogen, pink rosary, protected rat liver from cholesterol poisoning damage ( Yang2016sao ).

Chemoprotective effects applicable to chemotherapy

Ginseng protects, according to available literature, healthy cells from apoptosis in chemotherapy without providing the same protection to the cancer cells that chemotherapy has to destroy. According to Shim2007cae , this supportive effect in chemotherapy can be attributed to the ginseng ginseng proteoglycan .

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