Ginseng is contraindicated in acute bacterial disease, because of its suppressive effect on inflammation and tendency to enhance immune response of type 1 (anti-viral and anti-cancer) goes at the expense of response type 2 (antibacterial). Ginseng compromising the sharpness of the immune response to acute bacterial infection. From a purely security reasons also I suggest not to use ginseng in the first trimester of pregnancy. In the later stages of pregnancy ginseng without any problems .
Other contraindications ginseng virtually no
There is a superstition that ginseng should not be taken at higher pressure. This superstition is totally false. Ginseng is not contraindicated in hypertension, while it is very suitable ( Han1998erg , Sung2000erg , Jovanovski2014erk ). Ginseng is also excellent for the elderly and for people suffering from diseases of civilization: atherosclerosis , diabetes , allergies and autoimmune diseases . Ginseng has beneficial effects, particularly in cardiac patients ( Jia2012cgm ).
Ginseng has practically no adverse effects
Ginseng is an adaptogen almost perfect, and as such has virtually no side effects. But because some people can not imagine medicine without side effects, ginseng is přimýšlejí. So we learn that the adverse effects of ginseng should include increased blood pressure, nervousness, insomnia, skin rash and diarrhea, which were in Article Siegel1979gas in the journal JAMA from r. 1979 and in Article Chen1981eas in the Journal of Traditional Chinese Medicine ( "Magazine TCM "), collectively called ginseng abuse syndrome - syndrome overdose of ginseng. Mentioned article of the year. 1979 was based on a questionnaire filled out by 133 patients with a history of taking ginseng. No experimental studies, these side effects of ginseng have confirmed there. Instead, there is a plethora of reports on individual patients, whose health deteriorated in the time taken ginseng ( Paik2015rcp ). These cases samozřemě prove nothing, because even those who are taking adaptogens health condition deteriorates sometimes. The EU also used the construct of "ginseng overdose syndrome" for the introduction of a maximum dose of ginseng 2 g / day, which is sometimes insufficient.
It is good to examine the side effects of ginseng because its security relied many patients. Past studies of TCM and experience show that ginseng aforementioned adverse effects has ( Paik2015rcp ). Certainly you can refuse, for example, claim that ginseng increases blood pressure (in fact acting against hypertension) or induced skin rash (in fact counteract allergies). Ginseng also - although mentally stimulating - does not cause insomnia. Ginseng is not caffeine. That ginseng itself does not affect the sleep-wake cycle has been shown in animals ( Lee1990cip , Huong1998aem ) and in humans ( Han2013erg ).
Unreliable sources describing the fictional side effects of ginseng are confusing to other researchers. On the Czech Internet is an unfortunate case of an article on ginseng under which it is signed by doc. RNDr. Lubomír Opletal, PhD., Contains a long section about side effects of ginseng. With doc. Opletal I've communicated, and he told me that he once wrote for the paper web Ordinace.cz and drew adverse effects of the above sources. Doc. Opletal not aware of any other studies confirming the toxicity of ginseng. To remedy article on Ordinace.cz but it was necessary cooperation publishers because doc. Opletal has rights to the aforementioned article does not own.
Ginseng has practically no drug interactions
Ginseng is harmless and virtually no toxic dose. Experimental studies have concluded that drug interactions are virtually nonexistent ginseng ( Ramanathan2016pdi ). Superstitions about drug interactions ginseng continue to circulate the world. In my opinion it is spread by those who want to challenge this ancient medicine within the broader protibylinné propaganda. Because if I look at the shameless article Messina2006hsf , which was published in the prominent medical journal and is 100% based on speculation or Article Miller1998hms ilk, no other phrase than protibylinné propaganda comes to mind (see also the response of readers Fughberman1999hms ). From a commercial point of view it is that ginseng competes paracelsovským drugs , which itself is not toxic and belong among adaptogens . On lists of fictional interactions ginseng appears warfarin anticoagulants in general, antihypertensive drugs, diuretics, digoxin, steroids and estrogens, insulin and antidiabetic agents and psychiatric (phenelzine and others blockers oxidase).
Often mentioned ginseng interaction with warfarin exist ( Zhu1999pig , Vaes2000iww , Lee2010ibw ). Propaganda theorists know that the rumor might not even be true to Zamak fact that it can be spread. Especially blatant slander are yet relatively effective because decent people do not take such a big difference between rumor and reality. Warfarin is an effective Paracelsian anticoagulant drug, which is used at high doses in other industries such as rat poison. The mechanism of death was internal bleeding. Poison warfarin stands out that due to delays in the action it can not rodents associated with taste pitfalls, and also that there is against him 100% antidote: vitamin K. Unlike warfarin ginseng itself, however, is an anticoagulant adaptogen , which is neither toxic in high doses. In addition, ginseng improves regeneration of blood vessels and protects the heart and brain from ischemic injury. Ginseng in fact does not impair the effect of warfarin, but it competes successfully.
Ginseng, amlodipine and other medicines for hypertension
Interaction of ginseng with amlodipine exists ( Ryu2014npi ). Even with other drugs against hypertension is found interactions with ginseng, which would be worth mentioning ( Ramanathan2016pdi ). Again, ginseng itself has an effect against the hypertension confirmed in animals ( Chow1976psc , Jeon2000ekr ) and human patients ( Han1998erg , Sung2000erg , Jovanovski2014erk ). More specifically, the effect of ginseng on blood pressure adaptogenic and stabilization.
Ginseng and digoxin
Interaction of ginseng with digoxin there ( Ramanathan2016pdi ). This interaction reports mention Chen2012him and Shi2012diw , but the experimental evidence exists. As in previous cases, that ginseng itself is beneficial drug in cardiac patients.
Ginseng, insulin and antidiabetic medicines
Interaction of ginseng with other antidiabetic drugs was observed ( Ramanathan2016pdi ). Ginseng actually diabetics slightly lowers blood sugar, because he belongs to adaptogenům effective against diabetes .
Ginseng is not toxic dose. It can be eaten as if it were ordinary food. It can also be used as a vegetable soup. Even at doses of tens of grams of ginseng is harmless ( Coon2002pgs , Kitts2000esg , Seely2008sep ). Cleaned panaxosidy have a toxic dose, however, it is extremely high ( Kaku1975css ).
Until recently, everyone said that ginseng is completely ineffective, it is essentially a placebo. Today, when its effectiveness is scientifically undisputed, it would be a mistake to leave again haunt lists of fictional interactions and side effects. In comparison with paracelsovskými medicine ginseng is extremely safe.