(Mai Men ton)
Sedoulek Japan is Asia's highly prized medicinal plant, which is probably best known for its use in the cardio-vascular diseases. A recent review of its traditional use and pharmacological properties Chen2016ojp . Tuber sedoulku, ophiopogonis Japonica Tuber, in TCM used to "release mucus relief from cough, the latent heat in the chest and cleanup mind" ( Chen2016ojp ). Sedoulek together with ginseng and Schisandra part of a ternary combination of TCM生脈散(Sen-Mai-san, literally "to induce pulse") which serves mainly for cardiovascular conditions, including conditions after stroke. In cardiac and stroke this mixture in purified form even injected ( Li2011sic ). It is also used two-component combination sedoulku ginseng.
Scientific medicine in the 20th century, this plant basically ignored. The exception was Japan, where they came from pioneering studies on sedoulku ( Kato1968sco , Arisawa1969sur , Kaneda1983sco , Ishikura1984acb ). The wider scientific community about this plant became interested in the essence and in the 90s of the 20th century - most of about 20 scientific studies published in the 20th century, dates from the time after. 1990. In the 21st century, the situation is completely different - only the first decade of scientific publications on Japanese sedoulku almost 100!
Research on pharmacological properties sedoulku focus on its traditional indications. Found that saponins sedoulku to affect calcium currents myocardial cells ( Tao2005smd , Tao2005esm ), while the polysaccharides (MDG-1 and j.) Protecting the heart during ischemia ( Zheng2007peo , Wang2010pmi , Wang2012pma , Zhang2016cpe ). The ethanol extract sedoulku experiment shown antithrombotic effect ( Kou2005iee ) and saponin D ophiopogonin protect vascular endothelial cells ( Qian2010oph ) and cardiac muscle ( Zhang2015oad ) from damage. Other saponins experiment again improving myocardial regeneration ( Lan2013ccf ). Sedoulek also has effects against diabetes . Symbiotic fungus in the roots sedoulku him again impart mild antimicrobial properties ( Liang2012aae ).
Sedoulek in our medicine
Sedoulek today (r. 2013) Central European public (including doctors) known only as an aquarium plant. But it was not always the case - it's already Czech herbarium from r. 1899 ( online ) about him says: "Sedoulek (Ophiopogon), namely grapes growing on Japan. The root is laying the foundations to sugar and then used for Salep. Also to give against dysentery against breast ailments, against diseases of the digestive system and others. " Czech herbarium already not explain that under "breast diseases" refers also heart disease and angina pectoris.
The medicine, which in the 20th century sedoulek ignored today, of course, rushes to say that all previous clinical studies need sedoulku do not show and some of its effects (eg. Ophiopogoninu antioxidant effect) can be easily replaced by other materials. And scientists like me have no choice but to agree. So if you decide to use sedoulek, do not for scientific reasons but for some others: for example, in deference to the magic of TCM, or a mere irrational affection for natural and exotic.
Ofiopogonin, ruscogenin, β-sitosterol, stigmasterol and other specific triterpenoids and proteoglycans.