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Neurological problems (paroxysmal dystonia)

... I have a lifetime (30 years), muscle cramps very similar to epilepsy, only shorter, often very intense: 1-2 min, about 200 a day, it varies greatly. Diagnosed as paroxysmal dystonia - a major factor stress. All my life I enjoy neurological drugs but if I was not trying to "optimize" ... I'd probably be dead, because this is not medicine. I've tried everything, it always overwhelms extreme stress, unfortunately it can not be avoided, how sick I live in the family, but I try to, take reasonable steps, very active, to eliminate the negative effects of my family to me ... about two years ago I tried Chinese tea (the best are pi lo chun and snow buds), which have until now and order and very good to me also makes ginseng. What they can not cope "medicine", ginseng very well be replaced: -) ... I want to ask what it contains, respectively. what mechanism could operate in the Chinese tea, because it I really can do a 200 and more, almost continuous convulsions, "relaxing 50". Morning spasm after spasm - a cup of tea and "welfare" ... When I told the doctor that let us see what it contains, and said nothing while we tried literally irrational drugs - for parkisoniky and under. Therefore, I as an expert ratios I want to ask you if you can not think of anything interesting? Thank you very much, Milan.

Dear Milan,

coordination of movement is for the body of a man-sized challenge, because it is on the border of the ability of our neural hardware. When incoming fiber lengths sometimes exceeding 1 m are tens of milliseconds required only to signal transmission and processing hundreds of other locomotor program. We do not have time to think about whether we use the biceps or triceps, just the result we want and hand movement to "make itself". Before spinal motor neuron front corner can command muscle movement are working to prepare tens and hundreds of brain systems in the cerebral cortex, basal ganglia and cerebellum. I would compare it to the orchestra, whose conductor is our will. When the orchestra plays a soloist or a general pause, so all players must be silent. In humans afflicted dyskinesia not - suppression of the activity of one or another automated system is incomplete and leads to unwanted movements.

Your description of symptoms is not enough detail - can be hundreds of causes. It is more than clear that physicians also have the aetiology of your seizures have no idea, but use their standard methods. Patient comes easily to GABA agonists : Valium, Rohypnol, Zolpidem, Valium, ... They have a thousand names, but only one effect - depressants brain via GABA receptors , the most frequent receptors in the brain . My opinion of them is clear - if you can ignore . This is killing flea hammer. You also get medication for with Parkinson's and "abnormal drugs", which will surely medication for schizophrenics or people with hyperactivity. Modulators of dopamine pathways ? They are popular because they take up on schizophrenia and some of parkinsonism . But I have a feeling that in your case will be dopamine receptors close, but still wrong.

You write that you makes good tea and ginseng . The active substance is tea, as well as coffee, caffeine . But tea also contains its own GABA agonist - theanine. Inhibitory GABA receptors are most abundant receptors in the brain, as the main interaction between brain neurons inhibition. Thus, if the first block the path of the nerve neuron activity, the second neuron conversely increases, and the third reduced again etc. If the neural pathways to form a ring, or network, the situation is even more complex. You ask me for the mechanism, but science can not answer. Even though we know that caffeine acts on adenosine receptors and ginseng on many different receptors, we are not able to deduce from this information the overall neural activity.

So to sum up: we scientists do not know basically nothing, and you have to help yourself as you can. The only thing I can suggest is what you are already doing - on his own to try what helps you and it will then hold. I am glad that ginseng helps you - in other cases, I was surprised at the potential neurological problems. You do well to experiment with different kinds - small change in the ratio panaxosidů may be due to their mutual antagonism major impact on the overall effect. You can also try ginseng flower, or American ginseng. As for the other options, it is difficult to advise. In your place I would try after a series of traditional psychoactive substances. Not typing, if you smoke. If not, try small doses nicotine medical or medicinal hemp (best to eat, because the smoke is harmful to the lungs). Word, try to think only to try, if you do not take chance. Well I would recommend to try a decoction of coca leaf, which is in contrast to snuff cocaine and harmless little addictive, but if the whole plant is not prohibited in our country. Furthermore, I would replace the commercial GABA agonists (drugs reassuring) Pacific kava kava plant (Piper methysticum), but which the EU also suffer unnecessary permitting problems. From what grows in Central Europe can try lemon balm, St. John's, on nerve regeneration royal jelly, miracles but it is not.

-boris-

Hello, thank you for the professional answer, not smoke, do not drink, eat exemplarily, the main factor is stress, that I know where it comes from, what comes, it comes, I have shifted intimate zone, so I need your "home" ... unfortunately I live in a "sick family". The seizures themselves: it's all about the tea, therefore I ask what can cause up to 50 percent more fall (sometimes) cramps after cup of pi-lo-chun, respectively. snow buds. And conversely, if I drink more than 2 servings per day (eg. 3, 4 cups, according watering) and causes the contrary cramps, but the "classic" as a typical cramp in the calf, and such then I can paradoxically get the "my". As far as ginseng, I tried ginseng TaiwanTCM Liang , generally on all medicines, teas and so on. respond sensitively and immediately after taking a couple of hours I know where I stand, I tried half a slice of ginseng, today the whole, the whole is too ... Ginseng lower quality (dried root) with boiling water with the addition of marigold, brewed about 10 minutes and then again bathed for about 2-3 minutes ... also makes his own. Especially in terms of ginseng damping effects of neurological drugs, and that would according to the doctor could take 5 fold overdose ... :-) well that I would not write with you ... For these two benefits can say that ginseng 6 year stronger, I try and compare and give info. Nice day Milan.

Dear Milan,

we found. You are blessed with extraversion and I will turn willingness to respond.

Let me repeat that I am very pleased with your interest and I am delighted by the fact that ginseng is good for you. It's for me redress, because today in medicine still puts emphasis on synthetic drugs, which are becoming more and more expensive, while ginseng doctors are still skeptical even about its effectiveness as such. However, despite the relatively high cost compared to the conventional herbal ginseng they are panaxosidy the balance substantially cheaper than synthetic active ingredients - if you take the hand well dried red ginseng root, up to 20% by weight thereof consists of pure active substance.

Regarding your other questions, basically coincide with those that you put me in my first letter. Answers to them should attentively read found already in my first answer, but I will bring them more after shovel. I do not know whether we properly understand with smoking. My suggestion was just that you tried nicotine as a drug, but not necessarily smoke inhalation. Nicotine is mostly harmful, but in some cases helps. These include some neurological problems related to dopamine tracks. Nicotine mention purely because most doctors have him in the role of a drug forgotten. It can be taken orally, transcutaneously or inhalation exists to secure so. Electric cigarette - smokeless nicotine inhaler.

Problems with your family I said silence - the need to move is clear, the financial problems are now in Central Europe rather the rule. This problem has no easy solution. Your life I did not want to discuss. When Captain Scott before 100 years ago, returned from the South Pole, the expedition caught the polar night and the snowstorm, with temperatures of -40 ° C. Expedition ran out of supplies and in addition to frostbitten feet. They considered suicide, but agreed that it will die a natural death on the march. But they did something else - they encamped, crawled into sleeping bags and gradually pomrzli them. Scott as the only after a week of waiting for better weather tried to get up - they found him in a frozen sleeping bag is open. Mr. Milan, if you can not do anything, at least, turn off your sleeping bag. Or adjust to sing Smoljak and vice.

I also passed over in silence neurophysiological nature of the action of tea on your dyskinesia, because I was ashamed to weave hypotheses about what they dare not explain or specialists. But I suspect that you are bluffing, solder with the image of the involvement of dopamine pathway recent speculative publications ( Lisman2008cfu , right), and which is derived from my own speculative exposure draft tea tree caffeine and theanine on this track (figure below). For example, you may notice that my drawing caffeine has a strong activation P2X receptors inhibitory interneurons (and potentially the entire chain of inhibitory interneurons), as well as on the actual pyramid cells, which represent the data output of the cerebral cortex. You can imagine that tea tree caffeine in low doses activates not only pyramidal cells but also inhibitory interneuron, which however increased activity of pyramidal cells dampen so that it is even less active than if the brain is no caffeine was, thus, your cramps weakens . At high concentration of caffeine, however, activation of pyramidal cells is so strong that even increased depressant, it neubrzdí interneurons and cramps are amplified. But this is only one of dozens of possible explanations. In a similar manner may be considered in theanine, which allegedly increases the level of the inhibitory neurotransmitter GABA. Whether it is at the active ingredient caffeine and theanine can check by testing coffee. If the coffee does not work, but tea yes, are you just key substances specifically tea tree. Then it would be understandable also that observing differences between the various (čajovníkovými) tea. Especially so. White tea, which relishes, should have a higher ratio of theanine to caffeine. The highest content of theanine is said to have Japanese tea Gyokuro.

In the scheme of Article Lismanova (top right) you can also notice the letters "AD" on the square neuron blue-green color. Acetylcholine and are just at the central acetylcholine receptors, nicotine acts of which I spoke earlier.

dopamine diagram of my

I hope my mechanistic speculations were completely incomprehensible. I knew neurophysiologist who suffered dyskinesia similar to yours. He was a very intelligent man who had apparently Pasteurovskou to study motivation and even from respect for I wrote this a more detailed answer.

-boris-

| 19.1.2009

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