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Analgesics ( "painkillers")

"Painkillers" - the most commonly prescribed drugs

analgesics ibuprofen (Brufen, Dolgit etc.) and paracetamol (Paralen, Panadol, Paramax, Coldrex etc.) are among the most commonly prescribed drugs. Aspirin (acetylsalicylic acid), which is available without a prescription, was introduced in the 50s in the Guinness Book of Records as the best-selling drug in the world. Acetylsalicylic acid is part and other popular medications (like Alnagon). Why are these drugs so popular? And why write about so many different drugs at once? Allow me to answer your first to your second question ...

Thousands of drugs, one effect - inhibition of cyclooxygenase

Like every police system, and the immune system uses communication . However, immune cells do not use radios for communication, but a special class of chemical molecules called prostanoids . Prostanoids, there are many types to transmit different signals, but all are produced by rolling the arachidonic acid by the enzyme cyclooxygenase. And the objective is the inhibitory effect of those mentioned painkillers. If aside from cyclooxygenase activity, the whole immune system falls into forced of silence. Inflammation stops , the pain has subsided , often to the delight of the patient. However, it is questionable whether the blanket exclusion across prostanoid communication optimal approach.

Ginseng - a modern alternative to Paralen, Brufen or aspirin

Of the 180 ginseng saponins least ten decreases the expression of cyclooxygenase and dangerous NO synthase 2

Among over 180 medicinal ginseng saponins family there will be up to 8 such, which have been shown strong inhibitory effect on transcription factor (NF) -κB responsible for gene expression of cyclooxygenase (COX2) and inducible NO synthase 2 (NOS2). Ginsenosides Rh 1 , Rh 2 , Rb 2 , Rd , Rg 1 , Re , Rg 3 and some of their metabolites such as 20 (S) -PPT and compound K showed a potent activity in inhibiting transcription factor (NF) -κB responsible for gene expression and NO synthase cyclooxygenase 2. This will directly align commercial cyclooxygenase inhibitors. If I likened inflammation to nastartovanému complex machine that must be stopped, then you can say that aspirin et al. They stop manual strangulation fuel supply hose, while ginseng turning the key in the ignition.

Ginseng is effective at a higher level than conventional analgesics, and its effect has been clinically proven many times

Ginseng COX NOS2 and also suppresses other inflammatory proteins induced factor (NF) -κB. Ginsenosides Rb 1 , Rc , Rd , F2 , and Rh 1 further show inhibition outpouring of histamine and leukotrienes from mast cells ( christensen2009gcb ), which would be the effect against allergy. Effect of ginseng painkillers and anti-allergy is now basically a clinically proven, just speak about it too.

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