In the literature, varicose veins problems are also referred to as " chronic venous insufficiency ". Varices are most frequently located on the lower extremities, rare on the abdomen, chest and upper extremities - varicose veins , other locus of the rectum - hemorrhoids and esophagus - varices of the esophagus (for liver cirrhosis ).
Venous varicose veins arise when a permanently elevated pressure occurs in the venous system weakened by the disease process. A single varicose veins ( hemoroid, for example ) heal itself - usually throbbing, thrombosis (ie, clogging with a blood clot) , atrophy, and taking over the veins of the body. Therefore, the inflammation and thrombosis observed in the varicose veins is not the cause of the evil, but rather the adaptive process by which our body tries to remove the damaged part of the blood stream. However, varicose veins of the lower limbs or esophagus varices , the cause of which is systemic ( high venous pressure ), will create new and new varices until the cause is eliminated.
Effect of adaptogens on venous varices
The healing effect on varicose veins and hemorrhoids is attributed to many medicinal plants (beetroot, vilino, leafnate, oak, pine, blueberry, vine leaf, hesperidin and routine, etc.). Of the existing drugs (venofarmak) used to prevent hemorrhoids and varicose veins, diosmin (Detralex) is essentially modified hesperidin from fruit, while tribenoside (Glyvenol) is a substance that has been devoted to dozens of publications since the 1960s, but whose effect has never been properly clarified ( Kikkawa2010ite ). In this situation, it turns out that the position of adaptogens and specifically ginseng in the prevention and treatment of venous varices is not weaker than that of other venopharmacs.
Mechanisms of ginseng action
The process of varices formation and healing has aspects of venous mechanics, aspects of immune (inflammation, thrombosis) and aspect of vascular regeneration . Therefore, the general anti-inflammatory and healing effects of ginseng may be applied to vessels known for long. Ginseng as a means of treating venous varices is also mentioned in popular literature ( Cruz2001lvv ).
1. Ginseng protects the venous endothelium
Several panaxosides have been found to protect and treat venous endothelium ( He2007peg , Kwok2010gpp , Cho2013gri ), prevent oxidative damage, reduce adhesion of leukocytes to venous endothelium, act antithrombotically and normalize the expression of proteins associated with vascular damage and thrombosis ( Sun2006epn , Chen2008enr , Park2013cai ) . Experimentally it was found that ginsenoside Rg 1 blocks the affected endothelium inflammatory effect of TNF-α and increases the decreased expression NO synthase 3 ( Ma2006pae ) whose product, nitric oxide (NO) , is a signal to healing processes in the endothelium.
2. Ginseng works against inflammation and pain
The anti-inflammatory effect appears to be one of the main effects of other venopharmacs, such as tribenoside / Glyvanol. ( Ruegg1974tai ) This is just the effect of ginseng. Among its content substances are several, with the effect of chronic inflammation and pain .
3. Ginseng influences capillary growth and improves healing processes
Red ginseng ( Morisaki1995mae ) as well as ginseng extract improve vein endothelium regeneration, angiogenesis growth and wound healing in general ( Kimura2006egs , Hong2009aes ). Of particular active compounds are frequently spoken of ginsenoside Rg 1 , which stimulates regeneration of capillaries ( Sengupta2004may ) and ginsenoside Rb 1 , whose modulatory effect on angiogenesis has apparently budivou ( Kimura2006egs ) and buffer component ( Leung2007gri , Sengupta2004may ). Ginsenoside Rb 1 is also mentioned in connection witheffect against atherosclerosis .