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7. ginsenoside Rb2

Ginsenoside Rb 2

It is a damaran, protopanaxadiol panaxoside:

Ginsenoside Rb2

R 1 = -Glc 2-1 Glc
R2 = -Glc 6-1 Ara (p)

  • In mice stressed by immobilization, the level of interleukin-6 decreased in plasma. It also decreased in vitro the production of IL-6 from macrophages with epinephrine / norepinephrine . ( Kim2003iii )
  • Gssd. Rb 2 , Rd , Rg 1 and Re have a strong inhibitory effect on the production of TNF-α microglia-activated lipopolysaccharides. ( Wu2007deg )
  • Gssd. Rb 1 and Rb 2 suppressed TNF-α production in mouse and human macrophages stimulated with lipopolysaccharides with an IC50 of ~ 50 μM, respectively. ~ 25 μM. ( Cho2001vie )
  • It reduced the proliferation of mitogen stimulated T-cell and B-lymphocytes of mouse spleen with an IC50 of about 25 μM, and also suppressed their IL-2 production with IC 50 ~ 13.3 μM. ( Cho2002gfp )
  • Protected immune cells (spleen in vitro) from damage by γ radiation. ( Lee2006ivr )

| 11.3.2009