Growth and regeneration of blood vessels - Incorporation of newly created capillaries into regenerative tissue. Problems of blood vessels are associated with traumas or post-operative conditions, very often with civilization diseases and natural aging .
Angiogenic effects of adaptogens
Effects on blood vessel regeneration - vascular regeneration and capillary growth are well known in adaptogens. They are traditionally used in heart disease , high blood pressure and chronic venous insufficiency (varicose veins, hemorrhoids, esophagus varices). For cosmetic problems to improve the appearance of the skin and to heal certain types of skin inflammation . Also for more serious injuries and convalescence of postoperative conditions . Significant are for seniors who often suffer from poor blood flow.
Protective and regenerative effect of ginseng on blood vessels
The protective and vascular effect (dozens of work, eg Li2008ibc ) is the essence of the protective effect of ginseng in heart disease . However, the ginseng also improves the regeneration (growth) of blood vessels after injury, and this is the essence of a significant part of its effectiveness in wound healing . It is also possible that ginseng positively affects the construction and remodeling of connective tissue. There are articles describing the use of ginseng against scarring ( Pazyar2012gpn , Yao2007epn ), second articles warning, warning doctors to forbid patients banned ( Pribitkin2001htw ), the same situation as the well-proven cardiac effects of ginseng. An overview of several representative studies is here:
- Total ginseng saponin accelerates capillary growth in the experimental model ( Morisaki1995mae ).
- Ginsenoside Rg 1 encourages capillary regeneration ( Sengupta2004may ).
- The mechanism of the angiogenic effect of ginsenoside Rg 1 also discusses Cheung2011gia .
- Ginsenoside Rg 3 improves capillary regeneration by acting on PPARγ receptors ( Kwok2012sg2 ).
- Ginsenoside Re improves angiogenesis and positively affects the cardiovascular system ( Peng2012grp ).
- The modulation effect of ginsenoside Rb 1 on angiogenesis appears to be exciting ( Kimura2006egs ) as well as the buffering component ( Leung2007gri , Sengupta2004may ).
- The total ginseng right extract has a positive effect on angiogenesis factors in the context of myocardial infarction ( Ahn2011rge ).
- Improve angiogenesis in ginseng by mentioning key reviews such as Chen2008cpe .
In addition to panaxosides, which accelerate the growth of blood vessels, there are those with capillary growth inhibitory effects (eg ginsenoside Rg 1 with Rb 1 ). This is not contradictory, the content of substances with opposite effects is common in adaptogens, and the scientists are well aware of the topic of vascular regeneration ( Sengupta2004may , Leung2007gri ).
It is known in glossy cells that they do not work in the blood vessels. However, science does not know whether its effect against the destruction of damaged vessels (see eg Wang2012glp ) is or is not clinically significant. It is well known that glossy cells in high enough doses protect the tissues from inflammation and have anticancer effects , but they do not know if it can inhibit their angiogenesis attributed to Cao2006glp , Li2012gas , Stanley2005gls, etc. It is also not clear how its potential inhibitory effect on angiogenesis would be manifested in wound healing . This type of question belongs to the open problems of adaptogen research. We use cancers, including those of blood, shine when we believe the non-scientific TČM, in which case it is advisable to consult the practitioner of this art.
Other adaptogens and medicinal plants with angiogenic effects
Other Panax species, such as P. notoginseng , whose total saponin at 0.1 μg / ml accelerate endothelial cell division, increase vascular growth factor levels, and promote capillary growth ( Hong2009aes ) also have proangiogenic effects . The plant with a positive effect on capillary regeneration will certainly be much more and I do not make any illusions that I would have a chance to mention everyone here. I found at least a few: According to Panossian2008psc , it is a Chinese schisandra , according to Majewska2011pap also a kozinec blanitý, Chinese parsley , sea buckthorn ( Hippophae rhamnoides ) and additionally aloe vera , whose positive effects on wound healing summarize Hashemi2015rpa .