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Joint pain

Acute joint pain is felt naturally after exercise. This pain is well known to athletes and generally physically hard working people. Chronic joint pain is present in more serious injuries and subsequent healing of the joint. Also, many seniors suffer from painless pain.

Healthy joints are constantly regenerating

People suffering from chronic joint pain often say they have worn joints. This is true only in part. In the course of life, joints are constantly wearing and repairing. The painful joint often hurts for several days, but then it regenerates itself in healthy individuals (and seniors). The problem arises only when this natural regeneration capacity decreases or completely disappears.

Arthritis and chronic joint pain

Chronic joint pain is usually caused by inflammation . Inflammation is an immune process and pain is its attribute. Joint inflammation refers to arthritis or osteoarthritis (if inflammation affects bone tissue). The primary mechanism of arthritis is the damage to the joint lining that leads to inflammation. Inflammation is accompanied by hyperalgesia (increased pain) and allodynia (perceiving painless sensations as painful). In the inflamed joint, the pain is then a movement or touch near the joint. Joint pain is normally a meaningful phenomenon - it tells us how long we have a damaged joint to relax and allow it to regenerate. However, there is an ineffective chronic arthritis (rheumatoid arthritis) which not only does not regenerate the joint but even destroys the joint long term.

Rheumatoid arthritis

Rheumatoid arthritis (rheumatism) is a complicated autoimmune disease. The point is that the white blood cells of the patient get mad for some reason and start seeing the problem where it is not - in healthy joint cartilage. The causes of this process are unclear, but the joint creates an inflammation in which the white blood cells try to destroy a non-existent enemy while dismantling the cartilage binders and the adjoining bone bones inside which, in their view, they are concealed of microbes or cancer. All autoimmune diseases are unpleasant, but rheumatoid arthritis is very specific in that it can affect other cartilaginous body tissues, specifically heart and arterial valves. Rheumatoid arthritis is not only a disease of seniors, it can also occur at a relatively young age. Physicians are often clueless or treated with global immunosuppressive drugs, such as corticosteroids, which lead to reduced immunity, infections, and a vicious circle of taking other and other Paracelsus drugs into the patient's daily diet.

Classical adaptogens against joint pain and arthritis

The causal effect of adaptogens against inflammation and pain is important in arthritis, where we are interested not only in the removal of pain, but also in the regeneration of the diseased joint or the removal of autoimmune disorder if this arthritis has been caused. In addition to classical adaptogens suitable for joint pains, I would like to mention other effective plants.

Panax spp.

There are dozens of works confirming the effect of ginseng of genuine and other ginseng ( American ginseng , notoginseng ) against arthritis and thus joint pain. It is mainly based on the mild action of panaxosides against acute pain and their strong action against chronic inflammation and pain. It is gisenoside Rb 1 , Rb 2 , Rg 1 and others. Their representative overview is here:

  • The extract of ginseng saponins (mainly gssd, Rg 3 , Rk 1 and Rg 5 ) served on the mouse model against arthritis ( Kim2010rgs ). A similar result was achieved by Endale2014krg .
  • Jhun2014rge illustrates the molecular mechanisms by which ginseng treats autoimmune arthritis.
  • Ginsenoside Rb 1 was involved in the murine anti-arthritis model of TNF-α blocking. ( Kim2007aeg )
  • Ginsenoside Rg 1 in the arthritis model protected the joints by inhibiting the differentiation and maturation of osteoclasts. ( Gu2014smp )
  • Gssd. Ro has opposed experimental inflammation and rheumatoid arthritis. ( Matsuda1990aag )
  • In in vitro arthritis models, the protective effect on chondrocytes was found in gssd. Rg 3 ( So2013peg ) and K ( Choi2 O3e ).
  • Compound K also showed a protective effect on arthritis in the rat model. ( Chen2014gmc )
  • According to a clinical study, Zhang2007cse performed on 84 patients with rheumatoid arthritis notoginseng after 4 weeks improved the condition of patients.
  • The notoginsengu extract has been effective against rheumatoid arthritis in the mouse model. ( Chang2007aeb )

Eleuterokok ostnitý

Eleutherococcus , an improperly Siberian ginseng , is an example of an adaptogen without a unique chemical ( Davydov2000es ), but as a mixture of phytochemicals. Its effect on the mouse model of arthritis is described by Takahashi2014pte . The anti-inflammatory effect of one of its components was described in the context of arthritis by the Yamazaki2007spc study.

Vitania snodárna

Vitaminic snoring (ashvaganda, incorrect Indian ginseng ) had an effect against inflammation and arthritis both in the rat model ( Rasool2006sew , Rasool2007pew , Gupta2014eae , Khan2015ews ) and in human patients ( Sumantran2007cpr , Singh2007wsi ). The mechanism of its effect is explained, for example, by Ichikawa2006wpa .

Other medicinal plants against arthritis and joint pain

Scientific reports indicate the potential effect against arthritis in many other plants. I would particularly like to introduce Soeken2003hmt , Long2001hmt and Setty2005hmc from the systematic reviews I studied. I have studied relatively a lot of effective plants. On the list you will find adaptogens and medicinal herbs, which have a common denominator effect on arthritis / joint pain:

  • Salidroside, the major pink rosary active agent, reported protective effects on rheumatic immune complications of rheumatoid arthritis in the rat model. ( Zhu2016saa )
  • Saussurea is one of the classic miraculous plants of TČM and acts against inflammation and pain. Rheumatoid arthritis is its traditional indication ( Chik2015sir , Long2001hmt ).
  • Genuine ginger has extensive anti-inflammatory effects and also works against arthritis ( Grzanna2005ghm ). Its efficacy against knee pain was clinically proven ( Tapsell2006hbh ).
  • Curcuma-related turmeric is also effective against chronic inflammation ( Bright2007cad ).
  • The Chinese gang belongs to traditional anti-arthritis media. His effect on arthritis is reviewed by Magdalou2015aso .
  • Chinese peony is a TCM plant with a traditional indication of joint pain ( Zhang2012mit ).

Natural drugs with a potential effect on joint pain are so many that I can not get them all. Opium polyphenols (tyrosol, oleuropein), citrus (naringin, hesperidin), vines (resveratrol, procyanidin) and teaspoon ( Kawaguchi2011eap ) also help with inflammation and autoimmunity. Naringin is also mentioned by Ahmad2014aaa against rheumatoid arthritis and other autoimmune diseases. Effects against inflammation and pain include lotus embryo , cannabis , capsaicin, fish and crawfish fats, garlic, cress ( Lepidium sativum , Raval2013aec ), Ayurveda ravenous ( Symplocos racemosa , Acharya2016cas ) and cedar ( Boswellia , Hamidpour2013frx ) Cock2015gap ) and certainly other plants that have escaped my attention.

Of the non- adapted plants , the poisonous Tripterygium wilfordii ( Lipsky1997pnt , Ramgolam2000tcm , Bao2011cht ), a poisonous spider ( Cissampelos , Semwal2014fap ), is mentioned a lot . Also, Symphytum officinale contains alkaloids for which I would hesitate to include it among adaptogens ( Stickel2000esc ), although it is a traditional horseradish anti-muscular and joint pain ( Staiger2012cco ). Pharmaceutical ornamental preparations are said to contain alkaloids and are safe ( Staiger2013crf ). For joint pain, the effect of exercise and healthy lifestyle ( Cramp2013nif ) must also be forgotten.

| 24.1.2018