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Cholinergic effects (memory protection)

Cholinergic model memory corruption

Like the depression may be roughly link serotonin and dopamine Parkinsonism, central acetylcholine system is associated with the memory. The standard model of memory corruption in research administration of cholinergic antagonist scopolamine. Substances whose effect on memory protection is demonstrated on a model skopolaminového damage usually at least slightly help even when common memory damaging diseases - Alzheimer's disease - even if its actual cause is physical destruction of neurons, accumulation of β-amyloid. For adaptogens protective effect on memory as nootropickým effect, therefore, we examine the impact of their content substances on the central acetylcholine receptors and biological pathways linked to them.

Cholinergic effects adaptogens - effect on memory

Many adaptogens have protective effects on the CNS . This has also led to research their effect on memory protection, which in turn is associated with the cholinergic system.


Ginseng ( Nitta1995pge ) and American ginseng ( Sloley1999age ) regulate scopolamine impaired learning in rats. This effect was attributed specifically ginsenosides Rg 1 ( Yamaguchi1995egi ) and ginsenosides Rb 1 ( benishin1991egr ), who allegedly also facilitates an outpouring of acetylcholine from the hippocampus. According Salim1997grr also ginsenoside Rb 1 zyvšuje expression of enzymes and transporters acetylcholine transmission - mRNA acetylransferázy choline and the like. Conflicting reports regarding gssd. Rb 1 gives Yamaguchi1996egi by which memory protects gssd. R 1 and R , but not gssd Rb 1 , Rd , F 2 , Rf , Rh 1 or 20-O-Glu-PPD . Gssd Rg 2 , Rg 3 , compound K and aglycon protopanaxatriol reversibly block the neuronal acetylcholine nicotinic receptor α3β4. ( Lee2003deb , Jeong2004sgr , Lee2009rlr ).

Other adaptogens

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